SARS-CoV-2 Antigenemia is Associated With Pneumonia in Children But Lacks Sensitivity to Diagnose Acute Infection.

Autor:	Damhorst GL; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA., Verkerke HP; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Harrington KRV; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA., McLendon K; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA., Lu A; Center for Childhood Infections and Vaccines, Department of Pediatrics at Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA., Perez MA; Center for Childhood Infections and Vaccines, Department of Pediatrics at Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA., Hussaini L; Center for Childhood Infections and Vaccines, Department of Pediatrics at Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA., Anderson EJ; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA.; Center for Childhood Infections and Vaccines, Department of Pediatrics at Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA., Stowell SR; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Roback JD; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA., Lam WA; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA.; Aflac Cancer & Blood Disorders Center at Children's Healthcare of Atlanta, Atlanta, GA.; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA., Rostad CA; Center for Childhood Infections and Vaccines, Department of Pediatrics at Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2023 Feb 01; Vol. 42 (2), pp. 130-135. Date of Electronic Publication: 2022 Jan 11.
DOI:	10.1097/INF.0000000000003779
Abstrakt:	Background: Nucleocapsid antigenemia in adults has demonstrated high sensitivity and specificity for acute infection, and antigen burden is associated with disease severity. Data regarding SARS-CoV-2 antigenemia in children are limited. Methods: We retrospectively analyzed blood plasma specimens from hospitalized children with COVID-19 or MIS-C. Nucleocapsid and spike were measured using ultrasensitive immunoassays. Results: We detected nucleocapsid antigenemia in 62% (50/81) and spike antigenemia in 27% (21/79) of children with acute COVID-19 but 0% (0/26) and 15% (4/26) with MIS-C from March 2020-March 2021. Higher nucleocapsid levels were associated with radiographic infiltrates and respiratory symptoms in children with COVID-19. Conclusions: Antigenemia lacks the sensitivity to diagnose acute infection in children but is associated with signs and symptoms of lower respiratory tract involvement. Further study into the mechanism of antigenemia, its association with specific organ involvement, and the role of antigenemia in the pathogenesis of COVID-19 is warranted. Competing Interests: CAR’s institution has received funds to conduct clinical research unrelated to this manuscript from BioFire Inc, GSK, MedImmune, Micron, Janssen, Merck, Moderna, Novavax, PaxVax, Pfizer, Regeneron, Sanofi-Pasteur. She is co-inventor of patented RSV vaccine technology unrelated to this manuscript, which has been licensed to Meissa Vaccines, Inc. EJA has consulted for Pfizer, Sanofi Pasteur, Janssen, and Medscape, and his institution receives funds to conduct clinical research unrelated to this manuscript from MedImmune, Regeneron, PaxVax, Pfizer, GSK, Merck, Sanofi-Pasteur, Janssen, and Micron. He also serves on a safety monitoring board for Kentucky BioProcessing, Inc. and Sanofi Pasteur. His institution has also received funding from NIH to conduct clinical trials of Moderna and Janssen COVID-19 vaccines. GLD, HPV, KRVH, KM, AL, MAP, LH, SRS, JDR, and WAL report no conflicts of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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