A Systematic Review of Mixed Studies Exploring the Effects of Probiotics on Gut-Microbiome to Modulate Therapy in Children With Autism Spectrum Disorder.

Autor:	Patel M; Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Atluri LM; General Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Gonzalez NA; Pediatrics, Medical University of Graz, Graz, AUT.; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Sakhamuri N; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Athiyaman S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, CA, USA., Randhi B; Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Gutlapalli SD; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Pu J; Psychiatry and Behavioral Sciences, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Zaidi MF; Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Khan S; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Dec 08; Vol. 14 (12), pp. e32313. Date of Electronic Publication: 2022 Dec 08 (Print Publication: 2022).
DOI:	10.7759/cureus.32313
Abstrakt:	Autism spectrum disorder(ASD) is a complex neurodevelopmental disorder characterized by social deficits, repetitive typical behaviors, insistence on the same routines, and communication impairments. The prevalence of ASD has increased in the past decade. While we are aware that there is no cure for ASD, attempts are being made to reduce its symptoms and improve the learning, overall growth, and well-being of ASD patients. Gastrointestinal (GI) symptoms are frequent occurrences in patients with ASD, but the underlying mechanisms are unknown. Recent studies show that the microbiota-gut-brain axis is the key modulator of neuropsychiatric health. Although fecal transplants have shown positive outcomes in treating dysbiosis and symptoms of autism, lifestyle modifications such as dietary intervention will prevent and treat this disorder without causing major adverse effects. Probiotics enhance the microbiome to provide necessary metabolites, which help in gut permeability, cognitive function, and immunity. In some studies, children with increased GI symptoms have also shown increased behavioral disturbances. In this study, a systematic review of mixed studies is conducted to obtain more robust and conclusive results. We included randomized controlled studies with larger sample sizes and specifications on probiotics. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Patel et al.)
Databáze:	MEDLINE
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