Low Serum Vitamin D Status Is Associated with Incident Alzheimer's Dementia in the Oldest Old.

Autor: Melo van Lent D; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX 78229, USA., Egert S; Institute of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, 53115 Bonn, Germany., Wolfsgruber S; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, Germany., Kleineidam L; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, Germany., Weinhold L; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, 53105 Bonn, Germany., Wagner-Thelen H; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, Germany.; Department of Psychiatry, Medical Faculty, University of Cologne, 50924 Cologne, Germany., Stoffel-Wagner B; Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 53127 Bonn, Germany., Bickel H; Department of Psychiatry, Technical University of Munich, 81675 Munich, Germany., Wiese B; WG Medical Statistics and IT-Infrastructure, Institute of General Practice, Hannover Medical School, 30625 Hannover, Germany., Weyerer S; Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159 Mannheim, Germany., Pentzek M; Institute of General Practice, Medical Faculty, Heinrich-Heine-University, 40227 Dusseldorf, Germany., Jessen F; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Department of Psychiatry, Medical Faculty, University of Cologne, 50924 Cologne, Germany., Schmid M; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, 53105 Bonn, Germany., Maier W; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, Germany., Scherer M; Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Riedel-Heller SG; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 01403 Leipzig, Germany., Ramirez A; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, Germany.; Department of Psychiatry, Medical Faculty, University of Cologne, 50924 Cologne, Germany., Wagner M; German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany.; Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, 53105 Bonn, Germany.
Jazyk: angličtina
Zdroj: Nutrients [Nutrients] 2022 Dec 23; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 23.
DOI: 10.3390/nu15010061
Abstrakt: Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
Databáze: MEDLINE