| Autor: |
Schreier VN; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, 4055 Basel, Switzerland., Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, 4055 Basel, Switzerland., Welle F; Product Safety and Analytics Department, Fraunhofer Institute for Process Engineering and Packaging (IVV), 85354 Freising, Germany. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 25; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 25. |
| DOI: |
10.3390/molecules28010173 |
| Abstrakt: |
Polyethylene terephthalate (PET) is one of the most widely used food contact materials due to its excellent mechanical properties and recyclability. Migration of substances from PET and assessment of compliance are usually determined by experimental testing, which can be challenging depending on the migrants of interest. Low concentrations and missing reference standards, among other factors, have led to inadequate investigation of the migration potential of PET oligomers. Migration modeling can overcome such limitations and is therefore a suitable starting point for exposure and risk assessment. In this study, the activation energy-based (E A ) model and the A P model were used to systematically evaluate the migration potential of 52 PET oligomers for 12 different application scenarios. Modeling parameters and conditions were evaluated to investigate their impact and relevance on the assessment of realistic exposures. Obtained results were compared with safety thresholds known from the concept of toxicological thresholds of concern. This allowed the evaluation and identification of oligomers and/or applications where migration or exposure levels may be associated with a potential risk because they exceed these safety thresholds. Overall, this study demonstrated that migration modeling can be a high-throughput, fast, flexible, and suitable approach for comprehensive exposure assessment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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