Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton.

Autor:	De Silva E; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Hong F; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Falet H; Versiti Blood Research Institute, Milwaukee, WI, United States.; Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States., Kim H; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, BC, Canada.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular biosciences [Front Mol Biosci] 2022 Dec 20; Vol. 9, pp. 1060361. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2022).
DOI:	10.3389/fmolb.2022.1060361
Abstrakt:	Platelets are anucleate cells that are essential for hemostasis and wound healing. Upon activation of the cell surface receptors by their corresponding extracellular ligands, platelets undergo rapid shape change driven by the actin cytoskeleton; this shape change reaction is modulated by a diverse array of actin-binding proteins. One actin-binding protein, filamin A (FLNA), cross-links and stabilizes subcortical actin filaments thus providing stability to the cell membrane. In addition, FLNA binds the intracellular portion of multiple cell surface receptors and acts as a critical intracellular signaling scaffold that integrates signals between the platelet's plasma membrane and the actin cytoskeleton. This mini-review summarizes how FLNA transduces critical cell signals to the platelet cytoskeleton. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 De Silva, Hong, Falet and Kim.)
Databáze:	MEDLINE
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