The Emerging Role of Probiotics and their Derivatives against Biofilm-Producing MRSA: A Scoping Review.

Autor: Jalalifar S; Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Mirzaei R; Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran., Motallebirad T; Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Razavi S; Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Talebi M; Microbial Biotechnology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2022 Dec 27; Vol. 2022, pp. 4959487. Date of Electronic Publication: 2022 Dec 27 (Print Publication: 2022).
DOI: 10.1155/2022/4959487
Abstrakt: Background: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main bacterial pathogens causing chronic infections, mainly because of its capacity to produce biofilm. Biofilm production is one of the underlying strategies for antibacterial drug resistance. Accordingly, preventing and attenuating biofilm production has become an emerging approach to controlling persistent infections. Therefore, this scoping review is aimed at surveying the published literature describing the usage of probiotics and their derivatives against biofilm-producing MRSA.
Methods: Updated literature searches were conducted across seven electronic databases including Web of Science, PubMed, Scopus, Cochrane Library, ProQuest, Embase, and Google Scholar to identify all original published articles about probiotics against MRSA. In this regard, studies were summarized and analyzed in the present review.
Results: In the reviewed studies, various microorganisms and compounds were used as probiotics as follows: Lactobacillus species (8 studies), Enterococcus species (4 studies), Bacillus species (2 studies), Streptomyces species (2 studies), Saccharomyces cerevisiae (1 study), Corynebacterium accolens (1 study), and Lactococcus lactis derived Nisin (3 studies). Based on our comprehensive search, 21 studies with eligibility criteria were included in the present review including 12 studies on clinical strains, 6 studies on ATCC, 2 studies simultaneously on clinical and standard strains, and finally 1 study on food sample.
Conclusions: Our study showed that there was an increasing trend in the number of publications reporting probiotics against biofilm-producing MRSA. The results of this scoping review could use to guide the undertaking of the subsequent systematic reviews. In summary, probiotics with antimicrobial and antibiofilm properties can use as an embedded agent in food products or as a biopharmaceutical in the prevention and treatment of MRSA infections.
Competing Interests: The authors report no declarations of interest.
(Copyright © 2022 Saba Jalalifar et al.)
Databáze: MEDLINE
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