A Comprehensive Review of Bradykinin-Induced Angioedema Versus Histamine-Induced Angioedema in the Emergency Department.
| Autor: | Jayasinghe M; Medicine, Nanjing Medical University, Nanjing, CHN., Caldera D; Internal Medicine, Nanjing Medical University, Nanjing, CHN., Prathiraja O; Medicine and Surgery, Nanjing Medical University, Nanjing, CHN., Jena R; Neurology/Internal Medicine, Bharati Vidyapeeth Medical College/Bharati Hospital, Pune, IND., Coffie-Pierre JA; Internal Medicine, Nanjing Medical University, Nanjing, CHN., Agyei J; Orthopedics, Komfo Anokye Teaching Hospital, Kumasi, GHA., Silva MS; Medicine and Surgery, Nanjing Medical University, Nanjing, CHN., Kayani AMA; Medicine and Surgery, Allama Iqbal Medical College, Lahore, PAK., Siddiqui OS; Medicine, Gujarat Medical Education and Research Society (GMERS) Medical College and Hospital, Patan, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2022 Nov 30; Vol. 14 (11), pp. e32075. Date of Electronic Publication: 2022 Nov 30 (Print Publication: 2022). |
| DOI: | 10.7759/cureus.32075 |
| Abstrakt: | Angioedema (AE) is a condition that is frequently encountered in the emergency department (ED). It is a rare condition with localized, asymmetrical swelling of the skin and/or mucosa that is frequently nonpruritic and primarily affects locations with loose connective tissue. Physicians must have a thorough understanding of this condition since it can cause fatal airway compromise, which might be the presenting symptom. Histamine-mediated AE is the most common type of AE seen in EDs. However, ED physicians must be on the lookout for the less common bradykinin-mediated types of AE as these do not respond to the same therapy as histamine-mediated AE. Hospitals may lack specialized drugs or protocols, and many ED staff may be unable to identify or treat bradykinin-mediated AE. It is crucial to understand the pathophysiology of the various kinds of AE in order to optimize treatment. The goal of this review paper is to provide an overview of the pathophysiology, clinical manifestations, and treatment options for bradykinin and histamine-induced AE in the ED. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Jayasinghe et al.) |
| Databáze: | MEDLINE |
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