Conductive Polymer-Coated 3D Printed Microneedles: Biocompatible Platforms for Minimally Invasive Biosensing Interfaces.

Autor: Keirouz A; Materials for Health Lab, Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, UK.; Centre for Biosensors, Bioelectronics and Biodevices (C3Bio), University of Bath, Bath, BA2 7AY, UK., Mustafa YL; Materials for Health Lab, Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, UK.; Centre for Biosensors, Bioelectronics and Biodevices (C3Bio), University of Bath, Bath, BA2 7AY, UK., Turner JG; Materials for Health Lab, Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, UK.; Centre for Biosensors, Bioelectronics and Biodevices (C3Bio), University of Bath, Bath, BA2 7AY, UK., Lay E; Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.; Centre for Therapeutic Innovation, University of Bath, Bath, BA2 7AY, UK., Jungwirth U; Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.; Centre for Therapeutic Innovation, University of Bath, Bath, BA2 7AY, UK., Marken F; Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK., Leese HS; Materials for Health Lab, Department of Chemical Engineering, University of Bath, Bath, BA2 7AY, UK.; Centre for Biosensors, Bioelectronics and Biodevices (C3Bio), University of Bath, Bath, BA2 7AY, UK.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2023 Apr; Vol. 19 (14), pp. e2206301. Date of Electronic Publication: 2023 Jan 03.
DOI: 10.1002/smll.202206301
Abstrakt: Conductive polymeric microneedle (MN) arrays as biointerface materials show promise for the minimally invasive monitoring of analytes in biodevices and wearables. There is increasing interest in microneedles as electrodes for biosensing, but efforts have been limited to metallic substrates, which lack biological stability and are associated with high manufacturing costs and laborious fabrication methods, which create translational barriers. In this work, additive manufacturing, which provides the user with design flexibility and upscale manufacturing, is employed to fabricate acrylic-based microneedle devices. These microneedle devices are used as platforms to produce intrinsically-conductive, polymer-based surfaces based on polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS). These entirely polymer-based solid microneedle arrays act as dry conductive electrodes while omitting the requirement of a metallic seed layer. Two distinct coating methods of 3D-printed solid microneedles, in situ polymerization and drop casting, enable conductive functionality. The microneedle arrays penetrate ex vivo porcine skin grafts without compromising conductivity or microneedle morphology and demonstrate coating durability over multiple penetration cycles. The non-cytotoxic nature of the conductive microneedles is evaluated using human fibroblast cells. The proposed fabrication strategy offers a compelling approach to manufacturing polymer-based conductive microneedle surfaces that can be further exploited as platforms for biosensing.
(© 2023 The Authors. Small published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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