Pulmonary Recovery 12 Months after Non-Severe and Severe COVID-19: The Prospective Swiss COVID-19 Lung Study.

Autor:	Lenoir A; Division of Pulmonary Medicine, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland, amihalache7@gmail.com.; Gesundheitsamt Fürstenfeldbruck, Fürstenfeldbruck, Germany, amihalache7@gmail.com., Christe A; Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Ebner L; Department of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Beigelman-Aubry C; Radiodiagnostic and Interventional Radiology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Bridevaux PO; Service de Pneumologie, Hôpital du Valais, Sion, Switzerland., Brutsche M; Lung Center, Kantonsspital St. Gallen, St. Gallen, Switzerland., Clarenbach C; Pulmonary Medicine, University Hospital Zurich, Zurich, Switzerland., Erkosar B; Division of Pulmonary Medicine, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland.; Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland., Geiser T; Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, Department of Pulmonary Medicine, University of Bern, Bern, Switzerland., Guler SA; Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, Department of Pulmonary Medicine, University of Bern, Bern, Switzerland., Heg D; CTU Bern, University of Bern, Bern, Switzerland., Lador F; Division of Pulmonary Medicine, Geneva University Hospitals, Geneva, Switzerland., Mancinetti M; Department of Internal Medicine, University and Hospital of Fribourg, Villars-sur-Glâne, Switzerland., Ott SR; Department of Pulmonary Medicine, St. Claraspital AG, Basel, Switzerland.; University of Bern, Bern, Switzerland., Piquilloud L; Adult Intensive Care Unit, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., Prella M; Division of Pulmonary Medicine, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Que YA; Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., von Garnier C; Division of Pulmonary Medicine, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Funke-Chambour M; Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.; Department for BioMedical Research, Department of Pulmonary Medicine, University of Bern, Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	Respiration; international review of thoracic diseases [Respiration] 2023; Vol. 102 (2), pp. 120-133. Date of Electronic Publication: 2022 Dec 23.
DOI:	10.1159/000528611
Abstrakt:	Background: Lung function impairment persists in some patients for months after acute coronavirus disease 2019 (COVID-19). Long-term lung function, radiological features, and their association remain to be clarified. Objectives: We aimed to prospectively investigate lung function and radiological abnormalities over 12 months after severe and non-severe COVID-19. Methods: 584 patients were included in the Swiss COVID-19 lung study. We assessed lung function at 3, 6, and 12 months after acute COVID-19 and compared chest computed tomography (CT) imaging to lung functional abnormalities. Results: At 12 months, diffusion capacity for carbon monoxide (DLCOcorr) was lower after severe COVID-19 compared to non-severe COVID-19 (74.9% vs. 85.2% predicted, p < 0.001). Similarly, minimal oxygen saturation on 6-min walk test and total lung capacity were lower after severe COVID-19 (89.6% vs. 92.2%, p = 0.004, respectively, 88.2% vs. 95.1% predicted, p = 0.011). The difference for forced vital capacity (91.6% vs. 96.3% predicted, p = 0.082) was not statistically significant. Between 3 and 12 months, lung function improved in both groups and differences in DLCO between non-severe and severe COVID-19 patients decreased. In patients with chest CT scans at 12 months, we observed a correlation between radiological abnormalities and reduced lung function. While the overall extent of radiological abnormalities diminished over time, the frequency of mosaic attenuation and curvilinear patterns increased. Conclusions: In this prospective cohort study, patients who had severe COVID-19 had diminished lung function over the first year compared to those after non-severe COVID-19, albeit with a greater extent of recovery in the severe disease group. (© 2022 The Author(s). Published by S. Karger AG, Basel.)
Databáze:	MEDLINE
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