Pearls & Oy-sters: Salt and Pepper Sign, PLNTY for Drug-Resistant Epilepsy.

Autor:	Paredes-Aragón EM; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru. elma.paredesaragon@lhsc.on.ca., AlKhaldi NA; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Burneo JG; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Lee D; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Ang LC; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Steven D; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., MacDonald M; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Herrera-Aramburú M; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru., Mirsattari SM; From the Departments of Clinical Neurological Sciences (E.M.P.-A., J.G.B., D.L., L.C.A., D.S., S.M.M.), Department of Clinical Neurological Sciences and Oncology (M.M), Epidemiology and Biostatistics (J.G.B., D.S.), Pathology and Laboratory Medicine (L.C.A.), Medical Imaging (S.M.M.), Medical Biophysics (S.M.M.), and Psychology (S.M.M.), Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; Department of Neurological Emergencies (E.M.P.-A.), National Institute of Neurology and Neurosurgery, Mexico City, Mexico; Department of Neurology (N.A.A.), King Fahad University Hospital, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; and Epilepsy Department (M.H.-A.), Neurology Division, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2023 Apr 18; Vol. 100 (16), pp. 791-795. Date of Electronic Publication: 2022 Dec 23.
DOI:	10.1212/WNL.0000000000206782
Abstrakt:	Drug-resistant epilepsy, defined as the failure of 2 or more antiseizure medications to achieve seizure freedom, is responsible for 2/3 of epilepsy cases. Tumors are responsible for up to 15% of all adult onset and up to 6% of childhood onset epilepsies. Among these tumors, commonly known subtypes DNET, ganglioglioma, and low-grade astrocytoma are often suspected. New advances in tumor classification have been made, with genetics playing a key role in tumor classification. Polymorphic low-grade neuroepithelial tumor of the young (PLNTY) is a highly epileptogenic subtype of tumors that may mimic low-grade gliomas but offer pathologic and genetic clues: oligodendroglioma-like cellular components and infiltration patterns and strong CD34-immunopositive stain. In addition, a key finding is radiologic: a unifocal abnormality best seen on MRI brain in FLAIR sequence as the "salt and pepper sign" and calcifications appreciated on CT head. (© 2022 American Academy of Neurology.)
Databáze:	MEDLINE
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