SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City.

Autor: Vandegrift KJ; Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.; The Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Yon M; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Surendran Nair M; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Gontu A; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Ramasamy S; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Amirthalingam S; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Neerukonda S; United States Department of Health and Human Services, Silver Spring, MD 20993, USA., Nissly RH; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Chothe SK; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Jakka P; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., LaBella L; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Levine N; Department of Animal Science, The Pennsylvania State University, University Park, PA 16802, USA., Rodriguez S; Department of Animal Science, The Pennsylvania State University, University Park, PA 16802, USA., Chen C; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA., Sheersh Boorla V; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA., Stuber T; National Veterinary Services Laboratories, Veterinary Services, U.S. Department of Agriculture, Ames, IA 50010, USA., Boulanger JR; White Buffalo, Inc., Chester, CT 06412, USA., Kotschwar N; White Buffalo, Inc., Chester, CT 06412, USA., Aucoin SG; City of New York Parks & Recreation, New York, NY 10029, USA., Simon R; City of New York Parks & Recreation, New York, NY 10029, USA., Toal KL; City of New York Parks & Recreation, New York, NY 10029, USA., Olsen RJ; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, TX 77030, USA.; Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA., Davis JJ; Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637, USA.; Division of Data Science and Learning, Argonne National Laboratory, Argonne, IL 60439, USA., Bold D; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA., Gaudreault NN; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA., Dinali Perera K; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA., Kim Y; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA., Chang KO; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA., Maranas CD; Department of Chemical Engineering, The Pennsylvania State University, University Park, PA 16802, USA., Richt JA; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS 66506, USA., Musser JM; Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, TX 77030, USA.; Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10021, USA., Hudson PJ; Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.; The Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA., Kapur V; The Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Animal Science, The Pennsylvania State University, University Park, PA 16802, USA., Kuchipudi SV; The Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Dec 12; Vol. 14 (12). Date of Electronic Publication: 2022 Dec 12.
DOI: 10.3390/v14122770
Abstrakt: There is mounting evidence of SARS-CoV-2 spillover from humans into many domestic, companion, and wild animal species. Research indicates that humans have infected white-tailed deer, and that deer-to-deer transmission has occurred, indicating that deer could be a wildlife reservoir and a source of novel SARS-CoV-2 variants. We examined the hypothesis that the Omicron variant is actively and asymptomatically infecting the free-ranging deer of New York City. Between December 2021 and February 2022, 155 deer on Staten Island, New York, were anesthetized and examined for gross abnormalities and illnesses. Paired nasopharyngeal swabs and blood samples were collected and analyzed for the presence of SARS-CoV-2 RNA and antibodies. Of 135 serum samples, 19 (14.1%) indicated SARS-CoV-2 exposure, and 11 reacted most strongly to the wild-type B.1 lineage. Of the 71 swabs, 8 were positive for SARS-CoV-2 RNA (4 Omicron and 4 Delta). Two of the animals had active infections and robust neutralizing antibodies, revealing evidence of reinfection or early seroconversion in deer. Variants of concern continue to circulate among and may reinfect US deer populations, and establish enzootic transmission cycles in the wild: this warrants a coordinated One Health response, to proactively surveil, identify, and curtail variants of concern before they can spill back into humans.
Databáze: MEDLINE
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