Bioactivity and antidiabetic properties of Malva parviflora L. leaves extract and its nano-formulation in streptozotocin-induced diabetic rats.

Autor:	Mohammed DM; Nutrition and Food Sciences Department, National Research Centre, Dokki, Cairo, 12622, Egypt., Elsayed N; Food Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt., Abou Baker DH; Medicinal and Aromatic Plants Department, National Research Centre, Dokki, Cairo, 12622, Egypt., Ahmed KA; Pathology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt., Sabry BA; Food Toxicology and Contaminants Department, National Research Centre, Dokki, Cairo, 12622, Egypt.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Dec 06; Vol. 8 (12), pp. e12027. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2022).
DOI:	10.1016/j.heliyon.2022.e12027
Abstrakt:	Diabetes is a drastic health problem resulting from an endocrine disorder. M. parviflora L. might represent an antioxidant-rich food source and thus applies to pharmaceutical and therapeutic applications in oxidative stress-related degenerative diseases. In the current work, we assessed the antidiabetic activity of M. parviflora L. leaves extract and its nano-formulation in rats. M. parviflora L. bioactivity was evaluated by both antioxidant and antimicrobial assays. The nano-formulation characteristics (Mass, TEM, and Zeta potential) were evaluated. Twenty-four male Sprague-Dawley rats were administered streptozotocin (STZ) intraperitoneally for only one dose (35 mg/kg body weight). All of the nutritional and biochemical parameters were statistically analyzed. The results showed that M. parviflora L. is rich in phenolics and flavonoids with high antioxidant action. The antifungal activity of the extract was evident, especially with Fusarium culmorum and aspergillus flavus . The extract and its nano-formulation have shown antidiabetic properties when tested on diabetic rats as they improved all the biochemical parameters; decreased glucose level in serum, increased insulin production, marked improvement in lipid profile, liver and kidney functions, and that was more proved with the histopathological examinations. Conclusively, M. parviflora L. extract and its nano-formulation could attenuate or effectively help in controlling diabetes through its therapeutic properties exhibited by the action of the plant antioxidant components. Competing Interests: The authors declare no conflict of interest. (© 2022 The Author(s).)
Databáze:	MEDLINE
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