Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring.

Autor: de Castro Vieira Carneiro CL; Instituto Superior de Ciências Biomédicas (ISCB), State University of Ceará, Ceará, Brazil., Chaves EMC; Instituto Superior de Ciências Biomédicas (ISCB), State University of Ceará, Ceará, Brazil., Neves KRT; Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Federal University of Ceará, Ceará, Brazil., Braga MDM; Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Federal University of Ceará, Ceará, Brazil., Assreuy AMS; Instituto Superior de Ciências Biomédicas (ISCB), State University of Ceará, Ceará, Brazil., de Moraes MEA; Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Federal University of Ceará, Ceará, Brazil., Aragão GF; Instituto Superior de Ciências Biomédicas (ISCB), State University of Ceará, Ceará, Brazil.; Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM), Federal University of Ceará, Ceará, Brazil.
Jazyk: angličtina
Zdroj: Birth defects research [Birth Defects Res] 2023 Mar 01; Vol. 115 (4), pp. 488-497. Date of Electronic Publication: 2022 Dec 18.
DOI: 10.1002/bdr2.2138
Abstrakt: Background: Glyphosate is a pesticide considered of low toxicity, but scientific evidences show it can be harmful to health. This study aimed to evaluate the toxicity in mice offspring exposed to glyphosate-based herbicide (GBH) during the intrauterine period.
Methods: Female matrices received glyphosate 0.3 mg/kg daily per oral throughout the gestational period, which was variable between 18 and 22 days. From the 25th until the 28th days post-birth, mice offspring were subjected to behavioral tests, and the prefrontal cortex was processed for immunohistochemical analysis.
Results: Two significant behavioral changes were observed: anxiety in the GLIF0.3 group, increase in the behavior burying marbles in the marble-burying test and hyperactivity, expressed by the significant increase of the crossing number in the open field test. The increased microglia, TNF-alpha, and astrocyte expression were also observed in the prefrontal cortex of offspring treated with GLIF0.3.
Conclusion: Exposure to GBH during mice intrauterine development induces hyperactive and anxious behavior, evidencing neuroinflammation.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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