| Autor: |
Duan P; Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China. minzhang@scut.edu.cn., Sun J; Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China. minzhang@scut.edu.cn., Zhu Z; Clinical Research Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510315, P. R. China., Zhang M; Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China. minzhang@scut.edu.cn. |
| Abstrakt: |
Via a copper-catalyzed three-component annulation reaction, we herein report a new method for the direct and syn -selective construction of cyclic ether-fused tetrahydroquinolines from readily available secondary anilines, saturated five or six-membered cyclic ethers, and paraformaldehyde. The synthesis features operational simplicity, excellent step and atom efficiency, good functionality and substrate compatibility. In comparison with the reported synthetic protocols capable of synthesizing N -alkyl fused tetrahydroquinolines, this newly developed chemistry allows access to both N -alkyl and N -aryl products. The current work complements the preparation of fused tetrahydroquinolines. |
