Individualized interventions and precision health: Lessons learned from a systematic review and implications for analytics-driven geriatric research.

Autor: Kahkoska AR; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Freeman NLB; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Jones EP; Health Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Shirazi D; Department of Medicine, California University of Science and Medicine, Colton, California, USA., Browder S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Page A; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sperger J; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Zikry TM; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Yu F; School of Information and Library Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Busby-Whitehead J; Division of Geriatric Medicine, Department of Medicine, Center for Aging and Health, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., Kosorok MR; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States., Batsis JA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Division of Geriatric Medicine, Department of Medicine, Center for Aging and Health, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Jazyk: angličtina
Zdroj: Journal of the American Geriatrics Society [J Am Geriatr Soc] 2023 Feb; Vol. 71 (2), pp. 383-393. Date of Electronic Publication: 2022 Dec 16.
DOI: 10.1111/jgs.18141
Abstrakt: Older adults are characterized by profound clinical heterogeneity. When designing and delivering interventions, there exist multiple approaches to account for heterogeneity. We present the results of a systematic review of data-driven, personalized interventions in older adults, which serves as a use case to distinguish the conceptual and methodologic differences between individualized intervention delivery and precision health-derived interventions. We define individualized interventions as those where all participants received the same parent intervention, modified on a case-by-case basis and using an evidence-based protocol, supplemented by clinical judgment as appropriate, while precision health-derived interventions are those that tailor care to individuals whereby the strategy for how to tailor care was determined through data-driven, precision health analytics. We discuss how their integration may offer new opportunities for analytics-based geriatric medicine that accommodates individual heterogeneity but allows for more flexible and resource-efficient population-level scaling.
(© 2022 The American Geriatrics Society.)
Databáze: MEDLINE
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