Vitamin E depletion is associated with subclinical axonal degeneration in juvenile horses.

Autor: Donnelly CG; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA., Finno CJ; Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, California, USA.
Jazyk: angličtina
Zdroj: Equine veterinary journal [Equine Vet J] 2023 Sep; Vol. 55 (5), pp. 884-890. Date of Electronic Publication: 2023 Jan 04.
DOI: 10.1111/evj.13907
Abstrakt: Background: Phosphorylated neurofilament heavy, a marker of neuroaxonal damage, is increased in horses with equine neuroaxonal dystrophy. However, the temporal dynamics of this biomarker during the post-natal risk period are not understood.
Objective: To measure serum and cerebrospinal fluid phosphorylated neurofilament heavy concentrations in juvenile foals across the post-natal window of susceptibility for equine neuroaxonal dystrophy.
Study Design: Case-control in vivo experimental study.
Methods: Concentrations of phosphorylated neurofilament heavy were measured using frozen serum and cerebrospinal fluid collected from 13 foals raised in a vitamin E deficient environment from 1 to 6 months of age. Four of these foals were produced by equine neuroaxonal dystrophy-affected dams, developed clinical signs consistent with equine neuroaxonal dystrophy and had a diagnosis confirmed by histopathology. The remaining nine foals, produced by healthy mares, were vitamin E depleted and remained clinically healthy. An additional cohort of foals, produced by healthy mares, were supplemented with vitamin E (α-tocopherol; α-TOH) from birth and sampled similarly.
Results: Serum α-TOH concentrations were significantly higher in vitamin E supplemented healthy foals. Serum phosphorylated neurofilament heavy concentrations did not differ significantly between groups at any time point. Cerebrospinal fluid phosphorylated neurofilament heavy concentrations increased with age in healthy vitamin E depleted foals (p < 0.001); an effect that was not observed in healthy vitamin E supplemented foals.
Main Limitations: A genetically susceptible cohort supplemented with vitamin E was not available for comparison.
Conclusion: We demonstrate that vitamin E depletion may elevate cerebrospinal fluid phosphorylated neurofilament heavy in otherwise healthy juvenile foals by 6 months of age. We highlight an important cofactor to consider when interpreting cerebrospinal fluid phosphorylated neurofilament heavy concentrations in juvenile horses.
(© 2022 EVJ Ltd.)
Databáze: MEDLINE
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