Oral microbiota in cancer: could the bad guy turn good with application of polyphenols?

Autor: Antoniraj MG; Department of Biotechnology, Alagappa University (Science Campus), Karaikudi 630 003, Tamil Nadu, India., Devi KP; Department of Biotechnology, Alagappa University (Science Campus), Karaikudi 630 003, Tamil Nadu, India., Berindan-Neagoe I; Research Center for Functional Genomics, Biomedicine and Translational Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; The Center for Advanced Medicine - Medfuture- 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.; The Department for Functional Genomics and Experimental Pathology, The Oncology Institute, 'Prof. Dr Ion Chiricuta', Cluj-Napoca, Romania., Nabavi SF; Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, (BN), Italy.; Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE), Baturite, Ceara, Brazil., Khayat Kashani HR; Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Aghaabdollahian S; Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran., Afkhami F; Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.; School of Dentistry, The University of Queensland, Brisbane, Qld, 4006, Australia., Jeandet P; Research Unit-Induced Resistance and Plant Bioprotection, University of Reims, EA 4707-USC INRAe 1488, SFR Condorcet FR CNRS 3417, 51687 Reims, France., Lorigooini Z; Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran., Khayatkashani M; Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, (BN), Italy., Nabavi SM; Advanced Medical Pharma (AMP-Biotec), Biopharmaceutical Innovation Centre, Via Cortenocera, 82030, San Salvatore Telesino, (BN), Italy.; Nutringredientes Research Center, Federal Institute of Education, Science and Technology (IFCE), Baturite, Ceara, Brazil.
Jazyk: angličtina
Zdroj: Expert reviews in molecular medicine [Expert Rev Mol Med] 2022 Dec 13; Vol. 25, pp. e1. Date of Electronic Publication: 2022 Dec 13.
DOI: 10.1017/erm.2022.39
Abstrakt: The human oral cavity is comprised of dynamic and polynomial microbes which uniquely reside in the microenvironments of oral cavities. The cumulative functions of the symbiotic microbial communities maintain normal homeostasis; however, a shifted microbiota yields a dysbiosis state, which produces local and systemic diseases including dental caries, periodontitis, cancer, obesity and diabetes. Recent research reports claim that an association occurs between oral dysbiosis and the progression of different types of cancers including oral, gastric and pancreatic ones. Different mechanisms are proposed for the development of cancer, such as induction of inflammatory reactions, production of carcinogenic materials and alteration of the immune system. Medications are available to treat these associated diseases; however, the current strategies may further worsen the disease by unwanted side effects. Natural-derived polyphenol molecules significantly inhibit a wide range of systemic diseases with fewer side effects. In this review, we have displayed the functions of the oral microbes and we have extended the report regarding the role of polyphenols in oral microbiota to maintain healthy conditions and prevention of diseases with emphasis on the treatment of oral microbiota-associated cancer.
Databáze: MEDLINE
Externí odkaz: