Placental chorioangioma with an emphasis on rare giant placental chorioangioma and associated maternal and perinatal outcome: Clinicopathological study in a single centre.

Autor: Vig T; Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India., Tirkey RS; Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India., Jacob SE; Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India., Manoj Kumar R; Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India., Yenuberi H; Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India., Rathore S; Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamil Nadu, India., Mahasampath G; Department of Bio-Statistics, Christian Medical College, Vellore, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: Journal of family medicine and primary care [J Family Med Prim Care] 2022 Sep; Vol. 11 (9), pp. 5116-5122. Date of Electronic Publication: 2022 Oct 14.
DOI: 10.4103/jfmpc.jfmpc_1708_21
Abstrakt: Context: Giant placental chorioangiomas (GPC) are exceedingly rare and harbour potential to cause feto-maternal complications with resultant morbidity.
Aims & Materials and Methods: A retrospective study using details from Department of Obstetrics & Gynaecology and Pathology is done to study the various clinical and pathological features of placental chorioangiomas with a special emphasis on the rare GPCs and associated complications.
Results: Over a period of 16 years, 20 cases were diagnosed as chorioangioma in our institution. 60% of these occurred in primigravida (n=12) and 71% cases carried a female foetus. Only 25% cases were > 30 years. Maternal and foetal complications occurred in 85% and 50% cases. Pre-term labour was the common maternal complication and foetal death/stillbirth was the most common foetal complication. There were 15 cases of GPC, 73% occurred in primigravida (n=11) and 75% of cases carried a female foetus. There were no cases of maternal death or recurrence. Primigravidity was associated with maternal complication in contrast to multigravidity (P = 0.049). Mean age of mothers with maternal complications and those without maternal complications reached statistical significance (P = 0.001). Though histologically all the cases were similar, calcification and infarction were seen exclusively in GPC cases.
Conclusion: GPCs are rare and our data adds evidence to use 4cm as an optimum cut-off in the definition. GPCs were associated with a high percentage of primigravidity, female foetus, and poorer outcome of pregnancy. Routine examination of placenta in unexplained foetal/perinatal demise must be stressed to detect microscopic evidence of chorioangioma.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Journal of Family Medicine and Primary Care.)
Databáze: MEDLINE
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