Hematological profiles of malaria-infected patients in an endemic area of Peru.

Autor: Pinedo-Cancino V; Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía, Centro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonía Peruana, Iquitos, Perú.; Facultad de Medicina Humana, Universidad Nacional de la Amazonía Peruana, Iquitos, Perú., Arista KM; Laboratorio de Investigación de Productos Naturales Antiparasitarios de la Amazonía, Centro de Investigación de Recursos Naturales, Universidad Nacional de la Amazonía Peruana, Iquitos, Perú., Valle-Campos A; Departamento de Ciencias Biológicas. Universidad Nacional Mayor de San Marcos, Lima, Perú., Saavedra-Langer R; Departamento de Bioquímica e Inmunología, Instituto de Ciencias Biológicas, Universidad Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Roca C; Departamento de Microbiología e Inmunología, Universidad de Carolina del Norte, Chapel Hill, Estados Unidos., Ramos-Rincón JM; Departamento de Medicina Interna, Hospital General Universitario de Alicante-ISABIAL, Alicante, España.; Departamento de Medicina Clínica, Universidad Miguel Hernández de Elche, Alicante, España., Calderón M; Laboratorio de Investigación en Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Perú., Branch OH; Lark Health, Estudios clínicos, Mountain View, California, Estados Unidos.
Jazyk: Spanish; Castilian; English
Zdroj: Revista peruana de medicina experimental y salud publica [Rev Peru Med Exp Salud Publica] 2022 Jul-Sep; Vol. 39 (3), pp. 336-344. Date of Electronic Publication: 2022 Dec 05.
DOI: 10.17843/rpmesp.2022.393.11908
Abstrakt: Objectives.: To evaluate the variation of hematological profiles of patients infected with uncomplicated Plasmodium vivax (Pv) and P. falciparum (Pf) malaria before, during and after treatment in a population of the Loreto region.
Materials and Methods.: This study was conducted between 2010 and 2012, in Zungarococha (Iquitos). The 425 participants had three visits (visit 1-day 0-before treatment, visit 2-day 7-during treatment, visit 3-day 28-after treatment), complete blood count, microscopic and molecular diagnosis (PCR).
Results.: At the first visit, 93 (21.9%) participants were found positive for Pv and 34 (8.0%) for Pf. All positives showed a reduction in hematocrit, white blood cell count (WBC), ablated and segmented neutrophils, eosinophils and platelets (p<0.001) compared to the negative group. A higher percentage of ablated neutrophils was found in Pf and segmented neutrophils in Pv compared to the negative group. Variations in hematological profiles were observed after treatment for both species; ablated neutrophils decreased, platelets increased, eosinophils increased at day 7 and declined at day 28, hematocrit and segmented neutrophils decreased at day 7 and normalized at day 28. Interspecies differences over time showed a bigger daily decrease in ablated neutrophils in Pv-infected when compared to Pf.
Conclusions.: The hematological profile in uncomplicated malaria-positive patients varies over time during and after treatment. These are indicators of disease progression and help in the therapeutic surveillance of Plasmodium-infected patients.
Databáze: MEDLINE
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