Combination of PI-RADS score and PSAD can improve the diagnostic accuracy of prostate cancer and reduce unnecessary prostate biopsies.

Autor:	Wang C; Department of Urology, The First Affiliated Hospital of USTC of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Yuan L; Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Shen D; Department of Urology, The First Affiliated Hospital of USTC of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Zhang B; Department of Urology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China., Wu B; Department of Urology, The First Affiliated Hospital of USTC of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Zhang P; Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Xiao J; Department of Urology, The First Affiliated Hospital of USTC of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Department of Urology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China., Tao T; Department of Urology, The First Affiliated Hospital of USTC of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2022 Nov 16; Vol. 12, pp. 1024204. Date of Electronic Publication: 2022 Nov 16 (Print Publication: 2022).
DOI:	10.3389/fonc.2022.1024204
Abstrakt:	Objectives: The purpose of this study is to evaluate the diagnostic accuracy of the clinical variables of patients with prostate cancer (PCa) and to provide a strategy to reduce unnecessary biopsies. Patients and Methods: A Chinese cohort that consists of 833 consecutive patients who underwent prostate biopsies from January 2018 to April 2022 was collected in this retrospective study. Diagnostic ability for total PCa and clinically significant PCa (csPCa) was evaluated by prostate imaging-reporting and data system (PI-RADS) score and other clinical variables. Univariate and multivariable logistic regression analyses were performed to figure out the independent predictors. Diagnostic accuracy was estimated by plotting receiver operating characteristic curves. Results: The results of univariate and multivariable analyses demonstrated that the PI-RADS score (P < 0.001, OR: 5.724, 95% CI: 4.517-7.253)/(P < 0.001, OR: 5.199, 95% CI: 4.039-6.488) and prostate-specific antigen density (PSAD) (P < 0.001, OR: 2.756, 95% CI: 1.560-4.870)/(P < 0.001, OR: 4.726, 95% CI: 2.661-8.396) were the independent clinical factors for predicting total PCa/csPCa. The combination of the PI-RADS score and PSAD presented the best diagnostic performance for the detection of PCa and csPCa. For the diagnostic criterion of "PI-RADS score ≥ 3 or PSAD ≥ 0.3", the sensitivity and negative predictive values were 94.0% and 93.1% for the diagnosis of total PCa and 99.2% and 99.3% for the diagnosis of csPCa, respectively. For the diagnostic criterion "PI-RADS score >3 and PSAD ≥ 0.3", the specificity and positive predictive values were 96.8% and 92.6% for the diagnosis of total PCa and 93.5% and 82.4% for the diagnosis of csPCa, respectively. Conclusions: The combination of the PI-RADS score and PSAD can implement the extraordinary diagnostic performance of PCa. Many patients may safely execute active surveillance or take systematic treatment without prostate biopsies by stratification according to the PI-RADS score and the value of PSAD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Wang, Yuan, Shen, Zhang, Wu, Zhang, Xiao and Tao.)
Databáze:	MEDLINE
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