Validation of a highly accelerated post-contrast wave-controlled aliasing in parallel imaging (CAIPI) 3D-T1 MPRAGE compared to standard 3D-T1 MPRAGE for detection of intracranial enhancing lesions on 3-T MRI.

Autor: Goncalves Filho ALM; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA., Awan KM; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA., Conklin J; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA., Ngamsombat C; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA.; Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Nakhon Pathom, Thailand., Cauley SF; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA., Setsompop K; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA., Liu W; Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China., Splitthoff DN; Siemens Healthcare GmbH, Erlangen, Germany., Lo WC; Siemens Medical Solutions Inc., Boston, MA, USA., Kirsch JE; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA., Schaefer PW; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA., Rapalino O; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA., Huang SY; Department of Radiology, Massachusetts General Hospital (MGH), Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. Susie.huang@mgh.harvard.edu.; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA. Susie.huang@mgh.harvard.edu.; Division of Neuroradiology, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, GRB-273A, Boston, MA, 02114, USA. Susie.huang@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: European radiology [Eur Radiol] 2023 Apr; Vol. 33 (4), pp. 2905-2915. Date of Electronic Publication: 2022 Dec 02.
DOI: 10.1007/s00330-022-09265-6
Abstrakt: Objectives: High-resolution post-contrast T1-weighted imaging is a workhorse sequence in the evaluation of neurological disorders. The T1-MPRAGE sequence has been widely adopted for the visualization of enhancing pathology in the brain. However, this three-dimensional (3D) acquisition is lengthy and prone to motion artifact, which often compromises diagnostic quality. The goal of this study was to compare a highly accelerated wave-controlled aliasing in parallel imaging (CAIPI) post-contrast 3D T1-MPRAGE sequence (Wave-T1-MPRAGE) with the standard 3D T1-MPRAGE sequence for visualizing enhancing lesions in brain imaging at 3 T.
Methods: This study included 80 patients undergoing contrast-enhanced brain MRI. The participants were scanned with a standard post-contrast T1-MPRAGE sequence (acceleration factor [R] = 2 using GRAPPA parallel imaging technique, acquisition time [TA] = 5 min 18 s) and a prototype post-contrast Wave-T1-MPRAGE sequence (R = 4, TA = 2 min 32 s). Two neuroradiologists performed a head-to-head evaluation of both sequences and rated the visualization of enhancement, sharpness, noise, motion artifacts, and overall diagnostic quality. A 15% noninferiority margin was used to test whether post-contrast Wave-T1-MPRAGE was noninferior to standard T1-MPRAGE. Inter-rater and intra-rater agreement were calculated. Quantitative assessment of CNR/SNR was performed.
Results: Wave-T1-MPRAGE was noninferior to standard T1-MPRAGE for delineating enhancing lesions with unanimous agreement in all cases between raters. Wave-T1-MPRAGE was noninferior in the perception of noise (p < 0.001), motion artifact (p < 0.001), and overall diagnostic quality (p < 0.001).
Conclusion: High-accelerated post-contrast Wave-T1-MPRAGE enabled a two-fold reduction in acquisition time compared to the standard sequence with comparable performance for visualization of enhancing pathology and equivalent perception of noise, motion artifacts and overall diagnostic quality without loss of clinically important information.
Key Points: • Post-contrast wave-controlled aliasing in parallel imaging (CAIPI) T1-MPRAGE accelerated the acquisition of three-dimensional (3D) high-resolution post-contrast images by more than two-fold. • Post-contrast Wave-T1-MPRAGE was noninferior to standard T1-MPRAGE with unanimous agreement between reviewers (100% in 80 cases) for the visualization of intracranial enhancing lesions. • Wave-T1-MPRAGE was equivalent to the standard sequence in the perception of noise in 94% (75 of 80) of cases and was preferred in 16% (13 of 80) of cases for decreased motion artifact.
(© 2022. The Author(s), under exclusive licence to European Society of Radiology.)
Databáze: MEDLINE
Externí odkaz: