Estimating the changing disease burden attributable to iron deficiency in South Africa, 2000, 2006 and 2012.

Autor:	Awotiwon OF; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za., Cois A; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa; Division of Health Systems and Public Health, Department of Global Health, Stellenbosch University, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za., Pacella R; Institute for Lifecourse Development, Faculty of Education, Health and Human Sciences, University of Greenwich, UK. Oluwatoyin.Awotiwon@mrc.ac.za., Turawa EB; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za., Dhansay MA; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa; Division of Human Nutrition, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa . Oluwatoyin.Awotiwon@mrc.ac.za., Stuijvenberg L; Non-communicable Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za., Labadarios D; Division of Human Nutrition, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za., Roomaney RA; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. rifqah.roomaney@mrc.ac.za., Neethling I; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa; Lnstitute for Lifecourse Development, Faculty of Education, Health and Human Sciences, University of Greenwich, UK. Oluwatoyin.Awotiwon@mrc.ac.za., Nojilana B; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. beatrice.nojilana@mrc.ac.za., Abdelatif N; Biostatistics Research Unit, South African Medical Research Council, Cape Town, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za., Bradshaw D; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa; Division of Epidemiology and Biostatistics, Department of Family Medicine and Public Health, University of Cape Town, South Africa . Oluwatoyin.Awotiwon@mrc.ac.za., Pillay-van Wyk V; Burden of Disease Research Unit, South African Medical Research Council, Cape Town, South Africa. Oluwatoyin.Awotiwon@mrc.ac.za.
Jazyk:	angličtina
Zdroj:	South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde [S Afr Med J] 2022 Sep 30; Vol. 112 (8b), pp. 684-692. Date of Electronic Publication: 2022 Sep 30.
DOI:	10.7196/SAMJ.2022.v112i8b.16485
Abstrakt:	Background: Worldwide, iron deficiency, and consequent iron-deficiency anaemia, remains the most common nutritional disorder. Iron-deficiency anaemia mostly affects young children and women of reproductive age, especially in Asia and Africa. Iron deficiency may contribute to disability directly or indirectly as a risk factor for other causes of death, and may rarely contribute to death. Objectives: To estimate the changing burden of disease attributable to iron deficiency in males and females (all ages) for the years 2000, 2006 and 2012 in South Africa (SA). Methods: The comparative risk assessment methodology developed by the World Health Organization (WHO) and the Global Burden of Diseases, Injuries, and Risk Factors Studies was used to estimate the burden attributable to iron deficiency in SA for the years 2000, 2006 and 2012. We attributed 100% of the estimated iron-deficiency anaemia burden across all age groups by sex to iron deficiency. For maternal conditions, the attributable burden to iron deficiency was calculated using the counterfactual method and applied to all women of reproductive age. The population attributable fraction calculated for these selected health outcomes was then applied to local burden estimates from the Second SA National Burden of Disease Study (SANBD2). Age-standardised rates were calculated using WHO world standard population weights and SA mid-year population estimates. Results: There was a slight decrease in the prevalence of iron-deficiency anaemia in women of reproductive age from ~11.9% in 2000 to 10.0% in 2012, although the prevalence of anaemia fluctuated over time (25.5% - 33.2%), with a peak in 2006. There has been a gradual decline in the number of deaths from maternal conditions attributable to iron deficiency in SA between 2000 (351 deaths (95% uncertainty interval (UI) 248 - 436)) and 2012 (307 deaths (95% UI 118 - 470)), with a peak in 2006 (452 deaths (95% UI 301 - 589)). Furthermore, our analysis showed a 26% decrease between 2000 and 2012 in the age-standardised burden rates from maternal conditions (truncated to 15 - 49 years) attributable to iron deficiency. Between 2000 and 2012, the age-standardised disability-adjusted life year (DALY) rate from iron-deficiency anaemia attributable to iron deficiency markedly decreased by 33% in males, and increased by 3% in females of all ages. Approximately 1.1 - 1.4% of all DALYs in SA from 2000 to 2012 were attributable to iron deficiency. Conclusion: Iron-deficiency anaemia prevalence can be markedly reduced if iron deficiency is eliminated. Hence it is essential to encourage, reappraise and strengthen the measures that have been put in place to address iron deficiency, especially in women of reproductive age and children.
Databáze:	MEDLINE
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