The effect of strontium content on physicochemical and osteogenic property of Sr/Ag-containing TiO 2 microporous coatings.

Autor: Wang YR; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, People's Republic of China., Yang NY; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, People's Republic of China., Sun H; Department of Pathology, college of basic medicine, North China University of Science and Technology, Tangshan, China., Dong W; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, People's Republic of China., Deng JP; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, People's Republic of China., Zheng TX; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, People's Republic of China., Qi MC; Department of Oral & Maxillofacial Surgery, College of stomatology, North China University of Science and Technology, Tangshan City, People's Republic of China.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2023 Apr; Vol. 111 (4), pp. 846-857. Date of Electronic Publication: 2022 Dec 01.
DOI: 10.1002/jbm.b.35195
Abstrakt: Strontium (Sr) is the most common element introduced into TiO 2 coatings to strengthen the osteogenic property of titanium implants. However, the optimal Sr content and its effect on osteogenic and physicochemical properties of the coatings need to be clarified. In the current study, TiO 2 microporous coatings with different contents of Sr (9.64-21.25 wt %) and silver (Ag) (0.38-0.75 wt %) were prepared via micro-arc oxidation technique. Sr contents did not change physicochemical properties of the coatings, including surface microstructure, micropore size and distribution, phase composition, roughness and hydrophilicity. Meanwhile, higher Sr contents (18.23-21.25 wt %) improved cytocompatibility, proliferation and alkaline phosphatase (ALP) activity of preosteoblasts, even the coatings underwent 30 days' PBS immersion. Furthermore, higher Sr contents facilitated preosteoblast growth and spreading, which are essential for their proliferation and osteogenic differentiation. Therefore, it is promising to incorporate higher Sr content (18.23-21.25 wt %) within TiO 2 microporous coatings to improve their osteogenic capability.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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