Bismuth(III) Complexes with Schiff Bases: Synthesis, Characterization, Interaction with Biomolecules, Antioxidant and Antimicrobial Activity.

Autor:	Gvozdev MY; Faculty of Chemistry, Belarusian State University, 4 Independence Avenue, 220030 Minsk, Belarus.; Research Institute for Physico-Chemical Problems of the Belarusian State University, Leningradskaya str. 14, 220030 Minsk, Belarus., Loginova NV; Faculty of Chemistry, Belarusian State University, 4 Independence Avenue, 220030 Minsk, Belarus., Ksendzova GA; Research Institute for Physico-Chemical Problems of the Belarusian State University, Leningradskaya str. 14, 220030 Minsk, Belarus., Osipovich NP; Research Institute for Physico-Chemical Problems of the Belarusian State University, Leningradskaya str. 14, 220030 Minsk, Belarus., Koval'chuk-Rabchinskaya TV; Faculty of Chemistry, Belarusian State University, 4 Independence Avenue, 220030 Minsk, Belarus., Faletrov YV; Research Institute for Physico-Chemical Problems of the Belarusian State University, Leningradskaya str. 14, 220030 Minsk, Belarus., Khodosovskaya AM; Faculty of Biology, Belarusian State University, 4 Independence Avenue, 220030 Minsk, Belarus., Evtushenkov AN; Faculty of Biology, Belarusian State University, 4 Independence Avenue, 220030 Minsk, Belarus.
Jazyk:	angličtina
Zdroj:	Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2022 Nov 18. Date of Electronic Publication: 2022 Nov 18.
DOI:	10.2174/1573406419666221118104019
Abstrakt:	Aims and Background: In contrast to antibiotics, metal complexes can realize more than one mechanism of biocidal action to fight multidrug-resistant bacterial strains (due essentially to the metal ions), involving targets like functional groups in the walls of microbial cells and various enzymes. Among the potential antimicrobials are Bi(III) complexes with diphenols. Objective: The present work aimed at synthesizing and investigating novel Bi(III) complexes with Schiff bases as potential antimicrobial and antioxidant agents. Methods: Bi(III) complexes were characterized by means of elemental analysis, FT-IR, UV-Vis, 1H NMR spectroscopy, XRD, cyclic voltammetry and conductivity measurements as well as biological methods. Results: The complexes are characterized by the formula Bi(L)2Cl and pyramidal geometry of their coordination cores BiO2N2Cl, wherein the Bi(III) cation is coordinated by hydroxyl and azomethine moieties. The ligands coordinate in their monoanionic forms. The complexes are more lipophilic and more bioactive against the bacteria tested than the ligands. Both the ligands and their complexes exhibited the capability for the Fe(III)-Cyt c reduction and displayed comparable reducing rates. All the compounds are characterized by the DPPH and ABTS radical scavenging activity, and they are more active reductants than Trolox in the CUPRAC assay too. The peculiarities of the interaction of the complexes with BSA suggest that Cys-34 of BSA is not a major binding site for these complexes. According to molecular docking studies, the complexes bind to BSA via non-covalent interactions. Conclusion: Bi(III) complexation with Schiff bases plays an important role in their antimicrobial and antioxidant activities as well as in their interaction with BSA. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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