Highway to heal : Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases.

Autor:	Joglekar MM; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands., Nizamoglu M; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands., Fan Y; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands., Nemani SSP; Department of Paediatric Pneumology &Allergology, University Children's Hospital, Schleswig-Holstein, Campus Lübeck, Germany.; Epigenetics of Chronic Lung Disease, Priority Research Area Chronic Lung Diseases; Leibniz Lung Research Center Borstel; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Germany., Weckmann M; Department of Paediatric Pneumology &Allergology, University Children's Hospital, Schleswig-Holstein, Campus Lübeck, Germany.; Epigenetics of Chronic Lung Disease, Priority Research Area Chronic Lung Diseases; Leibniz Lung Research Center Borstel; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Germany., Pouwels SD; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, Netherlands., Heijink IH; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Department of Pulmonology, Groningen, Netherlands., Melgert BN; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.; University of Groningen, Department of Molecular Pharmacology, Groningen Research Institute for Pharmacy, Groningen, Netherlands., Pillay J; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Department of Critical Care, Groningen, Netherlands., Burgess JK; University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands.; University of Groningen, University Medical Center Groningen, W.J. Kolff Institute for Biomedical Engineering and Materials Science-FB41, Groningen, Netherlands.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2022 Nov 03; Vol. 13, pp. 995051. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).
DOI:	10.3389/fphar.2022.995051
Abstrakt:	Environmental insults including respiratory infections, in combination with genetic predisposition, may lead to lung diseases such as chronic obstructive pulmonary disease, lung fibrosis, asthma, and acute respiratory distress syndrome. Common characteristics of these diseases are infiltration and activation of inflammatory cells and abnormal extracellular matrix (ECM) turnover, leading to tissue damage and impairments in lung function. The ECM provides three-dimensional (3D) architectural support to the lung and crucial biochemical and biophysical cues to the cells, directing cellular processes. As immune cells travel to reach any site of injury, they encounter the composition and various mechanical features of the ECM. Emerging evidence demonstrates the crucial role played by the local environment in recruiting immune cells and their function in lung diseases. Moreover, recent developments in the field have elucidated considerable differences in responses of immune cells in two-dimensional versus 3D modeling systems. Examining the effect of individual parameters of the ECM to study their effect independently and collectively in a 3D microenvironment will help in better understanding disease pathobiology. In this article, we discuss the importance of investigating cellular migration and recent advances in this field. Moreover, we summarize changes in the ECM in lung diseases and the potential impacts on infiltrating immune cell migration in these diseases. There has been compelling progress in this field that encourages further developments, such as advanced in vitro 3D modeling using native ECM-based models, patient-derived materials, and bioprinting. We conclude with an overview of these state-of-the-art methodologies, followed by a discussion on developing novel and innovative models and the practical challenges envisaged in implementing and utilizing these systems. Competing Interests: MN, IHH, BNM, and JKB receive unrestricted research funds from Boehringer Ingelheim. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Joglekar, Nizamoglu, Fan, Nemani, Weckmann, Pouwels, Heijink, Melgert, Pillay and Burgess.)
Databáze:	MEDLINE
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