| Autor: |
Polyakova AA; Saint-Petersburg State Pediatric Medical University, 2 Litovskaya str., St. Petersburg 194100, Russian Federation, e-mail: vopol@yandex.ru., Medvedev DS; Research Institute of Hygiene, Occupational Pathology and Human Ecology FMBA of Russia, bldg. № 93 Kapitolovo, Vsevolozhsky district, Leningrad region 188663, Russian Federation.; Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo pr., St. Petersburg 197110, Russian Federation., Kozlov KL; Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo pr., St. Petersburg 197110, Russian Federation.; S.M.Kirov Military Medical Academy, 6 Academician Lebedev str., St. Petersburg 194044, Russian Federation., Polyakova VO; Saint-Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky pr., St. Petersburg 191036, Russian Federation., Drobintseva AO; Saint-Petersburg State Pediatric Medical University, 2 Litovskaya str., St. Petersburg 194100, Russian Federation, e-mail: vopol@yandex.ru.; Saint-Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky pr., St. Petersburg 191036, Russian Federation. |
| Abstrakt: |
Most patients over 50 years of age are diagnosed with diseases of the dentoalveolar apparatus, in particular, bone tissue disorders, which leads to a decrease in the survival rate of implants. Identification of the causes, as well as the development of a methodology for predicting survival by minimally invasive methods, is relevant. The aim of the study was to study the markers of tight junctions in the buccal epithelium (BE) in people of different ages. BE scrapings were taken before and after implantation in patients divided into 5 age groups, from young to centenarians. Immunocytochemical method was used to study markers for tight junction proteins - claudin-1, -7 and 10. It has been shown that with age there is a decrease in the intensity of expression of adhesion molecules, in particular claudin -1, -7 and -10 in the mucous membranes, the minimum values were recorded in the group of centenarians. The study found that after dental implantation, there was a decrease in the expression of claudin-1 and -10 and an increase in the expression of claudin-7. Changes in the expression of claudins may indicate the development of a pathological process in the body, including the success of implantation, especially in people of older age groups. |
