Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience.

Autor:	Marcolongo-Pereira C; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Castro FCAQ; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Barcelos RM; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Chiepe KCMB; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Rossoni Junior JV; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Ambrosio RP; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Chiarelli-Neto O; Coordenadoria de Pesquisa, Pós-Graduação e Extensão (CEPEG), Centro Universitário do Espírito Santo (UNESC), Colatina, Brazil., Pesarico AP; Curso de Medicina, Universidade Federal do Pampa (Unipampa), Bagé, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in behavioral neuroscience [Front Behav Neurosci] 2022 Oct 28; Vol. 16, pp. 1006836. Date of Electronic Publication: 2022 Oct 28 (Print Publication: 2022).
DOI:	10.3389/fnbeh.2022.1006836
Abstrakt:	Stress is an important factor in the development of several human pathologies. The response of rodents and humans to stress depends on many factors; some people and rodents develop stress-related mood disorders, such as depression and anxiety in humans, depression-like and anxiety-like behavior in mice and rats, while others report no new psychological symptoms in response to chronic or acute stress, and are considered susceptible and resilient to stress, respectively. Resilience is defined as the ability to thrive in the face of adversity and is a learned process that can help protect against occupational stressors and mental illnesses. There is growing interest in the underlying mechanisms involved in resilience and vulnerability to depression caused by stress, and some studies have demonstrated that individual variability in the way animals and humans respond to stress depends on several mechanisms, such as oxidative stress, neuronal plasticity, immunology and genetic factors, among others not discussed in this review, this review provides a general overview about this mechanism. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Marcolongo-Pereira, Castro, Barcelos, Chiepe, Rossoni Junior, Ambrosio, Chiarelli-Neto and Pesarico.)
Databáze:	MEDLINE
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