Migraine and Gastroparesis.

Autor: Arca KN; Department of Neurology, Mayo Clinic Arizona, Scottsdale, AZ, USA. arca.karissa@mayo.edu., Cai J; Department of Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA., Wang F; Department of Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA., Kassim G; Department of Gastroenterology, Mayo Clinic Arizona, Scottsdale, AZ, USA., Hasler WL; Department of Gastroenterology, Mayo Clinic Arizona, Scottsdale, AZ, USA., Batheja MJ; Department of Gastroenterology, Mayo Clinic Arizona, Scottsdale, AZ, USA.
Jazyk: angličtina
Zdroj: Current neurology and neuroscience reports [Curr Neurol Neurosci Rep] 2022 Dec; Vol. 22 (12), pp. 813-821. Date of Electronic Publication: 2022 Nov 12.
DOI: 10.1007/s11910-022-01241-3
Abstrakt: Purposeof Review: Migraine is a chronic and disabling disease affecting a significant proportion of the world's population. There is evidence that gastroparesis, a gastrointestinal (GI) dysmotility disorder in which transit of gastric contents is delayed, can occur in the setting of migraine. This article aims to review recent literature on overlap in the pathophysiology and clinical manifestations of migraine and gastroparesis and highlight management considerations when these disorders coexist.
Recent Findings: There has been increasing recognition of the importance of the connection between the GI tract and the brain, and mounting evidence for the overlap in the pathophysiology of migraine and gastroparesis specifically. There exists a complex interplay between the central, autonomic, and enteric nervous systems. Studies show that gastroparesis may be present during and between acute migraine attacks necessitating modification of management to optimize outcomes. Gastric dysmotility in the setting of migraine can impact absorption of oral migraine medications and alternate formulations should be considered for some patients. Noninvasive vagus nerve stimulation has been FDA cleared for migraine treatment and is also being studied in gastroparesis. Dysfunction of the autonomic nervous system is a significant feature in the pathophysiology of gut motility and migraine, making treatments that modulate the vagus nerve attractive for future research.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: