Sputnik Light and Sputnik V Vaccination Is Effective at Protecting Medical Personnel from COVID-19 during the Period of Delta Variant Dominance.

Autor: Sukhikh GT; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health, 117997 Moscow, Russia., Priputnevich TV; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health, 117997 Moscow, Russia., Ogarkova DA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Pochtovyi AA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Kustova DD; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Zlobin VI; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Logunov DY; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia., Gushchin VA; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Virology, Biological Faculty, Lomonosov Moscow State University, 119991 Moscow, Russia., Gintsburg AL; Federal State Budget Institution 'National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya' of the Ministry of Health of the Russian Federation, 123098 Moscow, Russia.; Department of Infectiology and Virology, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov, First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119435 Moscow, Russia.
Jazyk: angličtina
Zdroj: Vaccines [Vaccines (Basel)] 2022 Oct 26; Vol. 10 (11). Date of Electronic Publication: 2022 Oct 26.
DOI: 10.3390/vaccines10111804
Abstrakt: Medical personnel are a group of people that often encounter infectious agents, leading to greater risk of contracting infectious diseases. Specific prevention of diseases in this group is a priority. The epidemiological effectiveness of COVID-19 prevention in the group of medical workers due to the emergence of new variants of concern of the SARS-CoV-2 virus has not been studied in sufficient depth. We conducted a study of the effectiveness of vaccine use to protect medical workers at a large medical center for obstetrics and gynecology in Moscow. Sputnik V and Sputnik Light were the main vaccines used for the prevention of COVID-19. The vaccines are based on a variant of the S-protein of the SARS-CoV-2 virus, with adenovirus serotypes 5 and 26 as the vector for delivery. Vaccination of employees occurred during the period in which the Delta variant was spreading. The overall epidemiological effectiveness was 81.7% (73.1-87.6%) during the period in which the Delta variant was dominant. During the period from the beginning of vaccination (26 November 2020) until 8 February 2022, the overall effectiveness was 89.1% (86.9-91.0%). As expected, the highest effectiveness during this period was obtained in the group that received the third and fourth doses-96.5% (75.0-99.5%). The severity of COVID-19 in the vaccinated group was significantly lower than in the unvaccinated group.
Databáze: MEDLINE
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