Maternal obesity in pregnancy and children's cardiac function and structure: A systematic review and meta-analysis of evidence from human studies.

Autor: den Harink T; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands., Roelofs MJM; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Limpens J; Medical Library, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Painter RC; Amsterdam Reproduction and Development, Amsterdam, The Netherlands.; Department of Obstetrics and Gynecology, Amsterdam UMC, Amsterdam Reproduction and Development, University of Amsterdam, Amsterdam, Netherlands., Roseboom TJ; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Amsterdam Reproduction and Development, Amsterdam, The Netherlands.; Department of Obstetrics and Gynecology, Amsterdam UMC, Amsterdam Reproduction and Development, University of Amsterdam, Amsterdam, Netherlands., van Deutekom AW; Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Division of Paediatric Cardiology, Department of Paediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Nov 08; Vol. 17 (11), pp. e0275236. Date of Electronic Publication: 2022 Nov 08 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0275236
Abstrakt: The prevalence of obesity is increasing worldwide. Experimental animal studies demonstrate that maternal obesity during pregnancy directly affects cardiac structure and function in their offspring, which could contribute to their increased cardiovascular disease (CVD) risk. Currently, a systematic overview of the available evidence regarding maternal obesity and alterations in cardiac structure and function in human offspring is lacking. We systematically searched the electronic databases Embase, MEDLINE and NARCIS from inception to June 29, 2022 including human studies comparing cardiac structure and function from fetal life onwards in offspring of women with and without obesity. The review protocol was registered with PROSPERO International Prospective Register of Systematic Reviews (identifier: CRD42019125071). Risk of bias was assessed using a modified Newcastle-Ottawa scale. Results were expressed using standardized mean differences (SMD). The search yielded 1589 unique publications, of which thirteen articles were included. Compared to offspring of women without obesity, fetuses of women with obesity had lower left ventricular strain, indicative of reduced systolic function, that persisted in infancy (SMD -2.4, 95% confidence interval (CI) -4.4 standard deviation (SD) to -0.4 SD during fetal life and SMD -1.0, 95% CI -1.6 SD to -0.3 SD in infancy). Furthermore, infants born to women with obesity had a thicker interventricular septum (SMD 0.6 SD, 95% CI 0.0 to 1.2 SD) than children born to women without obesity. In conclusion, cardiac structure and function differs between fetuses and children of women with and without obesity. Some of these differences were present in fetal life, persisted in childhood and are consistent with increased CVD risk. Long-term follow-up research is warranted, as studies in offspring of older age are lacking.
Competing Interests: The authors have no competing interests to declare that are relevant to the content of this article.
(Copyright: © 2022 den Harink et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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