Intake of prebiotic fibers and the risk of laryngeal cancer: the PrebiotiCa study.

Autor: Turati F; Unit of Medical Statistics and Biometry, IRCCS National Cancer Institute of Milan, Milan, Italy. federica.turati@unimi.it.; Department of Clinical Sciences and Community Health, University of Milan, Via G. Celoria, 22, 20133, Milan, Italy. federica.turati@unimi.it., Concina F; Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy., Bertuccio P; Department of Clinical Sciences and Community Health, University of Milan, Via G. Celoria, 22, 20133, Milan, Italy.; Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy., Fiori F; Department of Medicine, University of Udine, Udine, Italy., Parpinel M; Department of Medicine, University of Udine, Udine, Italy., Taborelli M; Unit of Cancer Epidemiology, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy., Rosato V; Unit of Medical Statistics and Biometry, IRCCS National Cancer Institute of Milan, Milan, Italy., Garavello W; Department of Otorhinolaryngology, School of Medicine and Surgery, University of Milano- Bicocca, Monza, Italy., Negri E; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., La Vecchia C; Department of Clinical Sciences and Community Health, University of Milan, Via G. Celoria, 22, 20133, Milan, Italy.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2023 Mar; Vol. 62 (2), pp. 977-985. Date of Electronic Publication: 2022 Nov 06.
DOI: 10.1007/s00394-022-03030-7
Abstrakt: Purpose: To evaluate whether the intake of specific fibers with prebiotic activity, e.g., inulin-type fructans (ITFs), fructo-oligosaccharides (FOSs), and galacto-oligosaccharides (GOSs), is associated with laryngeal cancer risk.
Methods: Within the PrebiotiCa study, we used data from a case-control study (Italy, 1992-2009) with 689 incident, histologically confirmed laryngeal cancer cases and 1605 controls. Six prebiotic molecules (ITFs, nystose [FOS], kestose [FOS], 1F-β-fructofuranosylnystose [FOS], raffinose [GOS] and stachyose [GOS]) were quantified in various foods via ad hoc conducted laboratory analyses. Subjects' prebiotic fiber intake was calculated by multiplying food frequency questionnaire intake by the prebiotic content of each food item. The odds ratios (OR) of laryngeal cancer for prebiotic fiber intake were calculated using logistic regression models, including, among others, terms for tobacco, alcohol, and total energy intake.
Results: The intakes of kestose, raffinose and stachyose were inversely associated with laryngeal cancer, with ORs for the highest versus the lowest quartile of 0.70 (95% confidence interval, CI 0.50-0.99) for kestose, 0.65 (95% CI 0.45-0.93) for raffinose and 0.61 (95% CI 0.45-0.83) for stachyose. ITFs, nystose and 1F-β-fructofuranosylnystose were not associated with laryngeal cancer risk. Current smokers and heavy drinkers with medium-low intakes of such prebiotic fibers had, respectively, an over 15-fold increased risk versus never smokers with medium-high intakes and a five to sevenfold increased risk versus never/moderate drinkers with medium-high intakes.
Conclusion: Although disentangling the effects of the various components of fiber-rich foods is complex, our results support a favorable role of selected prebiotic fibers on laryngeal cancers risk.
(© 2022. The Author(s).)
Databáze: MEDLINE
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