| Autor: |
Mohandoss S; School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea., Ganesan S; Department of Environmental Engineering and Management, Chaoyang University of Technology, Taichung, Taiwan., Velsankar K; Department of Physics, Alagappa University, Karaikudi, Tamil Nadu, India., Sudhahar S; Department of Physics, Alagappa University, Karaikudi, Tamil Nadu, India., Alkallas FH; Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Trabelsi ABG; Department of Physics, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Kusmartsev FV; Department of Physics, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates., Lo HM; Department of Environmental Engineering and Management, Chaoyang University of Technology, Taichung, Taiwan., Lee YR; School of Chemical Engineering, Yeungnam University, Gyeongsan, Republic of Korea. |
| Abstrakt: |
Hydrogel nanocomposites are attracting increasing attention in field of biology owing to their unique properties. The present work focuses on the fabrication and characterization of novel hydrogel nanocomposite systems in which silver nanoparticles (AgNPs) are embedded in a carrageenan ( κ -CGN)-sodium alginate (SA) hydrogel. The performance of the prepared κ -CGN-SA hydrogel and κ -CGN-SA/AgNPs hydrogel nanocomposite was determined by UV-visible spectroscopy, FTIR, XRD, SEM, EDX spectrum, EDX mapping, and TEM analysis. Surface plasmon resonance at 428 nm confirmed the presence of AgNPs in the κ-CGN-SA hydrogel. The results indicate that AgNPs with an average diameter of 30 nm were uniformly dispersed in the κ-CGN-SA hydrogel matrix. The amount of Ag + ion release kinetic from the κ-CGN-SA hydrogel matrix is very low, showing that AgNPs were well trapped within the κ -CGN-SA/AgNPs hydrogel nanocomposite. The high antibacterial activity of the κ-CGN-SA/AgNPs hydrogel nanocomposite was found to be 89.6 ± 1.4% and 91.4 ± 2.3% against the gram-positive S. aureus and the gram-negative E. coli , respectively. Moreover, the κ -CGN-SA/AgNPs hydrogel nanocomposite showed good biocompatibility by the MTT test. The novel κ -CGN-SA/AgNPs hydrogel nanocomposite low cytotoxicity and antibacterial efficacy is proposed as a potential candidate for biomedical applications. |
