CRISPR-assisted transposition: TnsC finds (and threads) the needle in the haystack.
| Autor: | Hossain AA; Laboratory of Bacteriology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA., Marraffini LA; Laboratory of Bacteriology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA; Howard Hughes Medical Institute, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA. Electronic address: marraffini@rockefeller.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2022 Nov 03; Vol. 82 (21), pp. 3968-3969. |
| DOI: | 10.1016/j.molcel.2022.10.014 |
| Abstrakt: | Hoffmann et al. (2022) demonstrate that RNA-guided transposons are remarkably sequence specific due to the action of a AAA+ ATPase, TnsC, that recruits the transposase to the correct target site. Competing Interests: Declaration of interests L.A.M. is a founder and advisor of Intellia Therapeutics and Eligo Biosciences. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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