Established and emerging roles for mitochondria in neutrophils.

Autor: Peng S; Institute of Pharmacology, University of Bern, Bern, Switzerland., Gao J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Stojkov D; Institute of Pharmacology, University of Bern, Bern, Switzerland., Yousefi S; Institute of Pharmacology, University of Bern, Bern, Switzerland., Simon HU; Institute of Pharmacology, University of Bern, Bern, Switzerland.; Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia.; Laboratory of Molecular Immunology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.; Institute of Biochemistry, Brandenburg Medical School, Neuruppin, Germany.
Jazyk: angličtina
Zdroj: Immunological reviews [Immunol Rev] 2023 Mar; Vol. 314 (1), pp. 413-426. Date of Electronic Publication: 2022 Nov 04.
DOI: 10.1111/imr.13158
Abstrakt: Neutrophils are the most abundant innate immune cells in human blood, emerging as important players in a variety of diseases. Mitochondria are bioenergetic, biosynthetic, and signaling organelles critical for cell fate and function. Mitochondria have been overlooked in neutrophil research owing to the conventional view that neutrophils contain few, if any, competent mitochondria and do not rely on these organelles for adenosine triphosphate production. A growing body of evidence suggests that mitochondria participate in neutrophil biology at many levels, ranging from neutrophil development to chemotaxis, effector function, and cell death. Moreover, mitochondria and mitochondrial components, such as mitochondrial deoxyribonucleic acid, can be released by neutrophils to eliminate infection and/or shape immune response, depending on the specific context. In this review, we provide an update on the functional role of mitochondria in neutrophils, highlight mitochondria as key players in modulating the neutrophil phenotype and function during infection and inflammation, and discuss the possibilities and challenges to exploit the unique aspects of mitochondria in neutrophils for disease treatment.
(© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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