Characteristics of the Ontario Neurodegenerative Disease Research Initiative cohort.

Autor:	Sunderland KM; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada., Beaton D; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada., Arnott SR; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada., Kleinstiver P; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Kwan D; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Lawrence-Dewar JM; Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada., Ramirez J; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Tan B; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada., Bartha R; Robarts Research Institute, Western University, London, Ontario, Canada.; Department of Medical Biophysics, Western University, London, Ontario, Canada., Black SE; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada., Borrie M; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; St. Joseph's Healthcare Centre, London, Ontario, Canada., Brien D; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Casaubon LK; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.; Toronto Western Hospital, Toronto, Ontario, Canada., Coe BC; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Cornish B; Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada., Dilliott AA; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Robarts Research Institute, Western University, London, Ontario, Canada., Dowlatshahi D; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Finger E; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Lawson Health Research Institute, London, Ontario, Canada., Fischer C; Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada., Frank A; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Bruyère Research Institute, Ottawa, Ontario, Canada., Fraser J; Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada., Freedman M; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, Baycrest Health Sciences, Toronto, Ontario, Canada., Greenberg B; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Grimes DA; Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Hassan A; Thunder Bay Regional Health Research Institute, Thunder Bay, Ontario, Canada., Hatch W; Kensington Eye Institute, Toronto, Ontario, Canada.; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada., Hegele RA; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Robarts Research Institute, Western University, London, Ontario, Canada., Hudson C; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.; School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada., Jog M; London Health Sciences Centre, London, Ontario, Canada., Kumar S; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Lang A; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada., Levine B; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.; Department of Psychology, University of Toronto, Toronto, Ontario, Canada., Lou W; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Mandzia J; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Department of Clinical Neurological Sciences, London Health Sciences Centre, London, Ontario, Canada., Marras C; Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada., McIlroy W; Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada., Montero-Odasso M; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Lawson Health Research Institute, London, Ontario, Canada.; Gait and Brain Lab, Parkwood Institute, London, Ontario, Canada., Munoz DG; Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada., Munoz DP; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Orange JB; School of Communication Sciences and Disorders, Elborn College, Western University, London, Ontario, Canada., Park DS; Hotchkiss Brain Institute, Calgary, Alberta, Canada.; Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada., Pasternak SH; St. Joseph's Healthcare Centre, London, Ontario, Canada.; Cognitive Neurology and Alzheimer's Disease Research Centre, Parkwood Institute, London, Ontario, Canada., Pieruccini-Faria F; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Lawson Health Research Institute, London, Ontario, Canada.; Gait and Brain Lab, Parkwood Institute, London, Ontario, Canada., Rajji TK; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Roberts AC; School of Communication Sciences and Disorders, Elborn College, Western University, London, Ontario, Canada.; Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois, USA., Robinson JF; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Robarts Research Institute, Western University, London, Ontario, Canada., Rogaeva E; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Sahlas DJ; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Saposnik G; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Research, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada., Scott CJM; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Seitz D; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Shoesmith C; London Health Sciences Centre, London, Ontario, Canada., Steeves TDL; Division of Neurology, St. Michael's Hospital, Toronto, Ontario, Canada., Strong MJ; Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.; Canadian Institutes for Health Research, Ottawa, Ontario, Canada., Strother SC; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Swartz RH; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada., Symons S; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada., Tang-Wai DF; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada.; Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada., Troyer AK; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Neuropsychology and Cognitive Health, Baycrest Health Sciences, Toronto, Ontario, Canada., Turnbull J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Zinman L; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada., McLaughlin PM; Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.; Nova Scotia Health, Halifax, Nova Scotia, Canada., Masellis M; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada., Binns MA; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jan; Vol. 19 (1), pp. 226-243. Date of Electronic Publication: 2022 Mar 30.
DOI:	10.1002/alz.12632
Abstrakt:	Introduction: Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods: This multi-site, longitudinal, observational cohort study recruited participants across prevalent neurodegenerative diseases and cerebrovascular disease and assessed participants comprehensively across modalities. We describe univariate and multivariate baseline features of the cohort and summarize recruitment, data collection, and curation processes. Results: We enrolled 520 participants across five neurodegenerative and cerebrovascular diseases. Median age was 69 years, median Montreal Cognitive Assessment score was 25, median independence in activities of daily living was 100% for basic and 93% for instrumental activities. Spousal study partners predominated; participants were often male, White, and more educated. Milder disease stages predominated, yet cohorts reflect clinical presentation. Discussion: Data will be shared with the global scientific community. Within-disease and disease-agnostic approaches are expected to identify markers of severity, progression, and therapy targets. Sampling characteristics also provide guidance for future study design. (© 2022 the Alzheimer's Association.)
Databáze:	MEDLINE
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