Right-left digit ratios, a novel form of asymmetry: Patterns of instability in children and relationships to platelet counts and hospitalization in adults with COVID-19.

Autor:	Kasielska-Trojan A; Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Lodz, Poland., Manning JT; Applied Sports, Technology, Exercise, and Medicine (A-STEM), Swansea University, Swansea, United Kingdom., Jabłkowski M; Department of Infectious and Liver Diseases, Medical University of Lodz, Lodz, Poland., Białkowska-Warzecha J; Department of Infectious and Liver Diseases, Medical University of Lodz, Lodz, Poland., Kwasniewska O; Medical University in Lodz, Lodz, Poland., Hirschberg AL; Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden., Antoszewski B; Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Lodz, Poland.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2022 Oct 14; Vol. 10, pp. 995025. Date of Electronic Publication: 2022 Oct 14 (Print Publication: 2022).
DOI:	10.3389/fpubh.2022.995025
Abstrakt:	High right minus left (R-L) asymmetry of digit ratios has been reported to be linked to hospitalization for COVID-19. Here we examined the developmental patterns of this novel form of asymmetry in children and further explored their relationships to platelet counts and hospitalization for COVID-19 in adult patients. We considered ratios calculated from four digits (2D, 3D, 4D, 5D) in: (i) a sample of healthy participants aged 2 years to 18 years ( n = 680, 340 males) and (ii) 96 adult patients (42 males) hospitalized for COVID-19 and 100 controls (53 males). The protocol for (ii) included a questionnaire and laboratory test results. In sample (i) of the six unsigned digit ratio asymmetries, those which included 5D had the highest mean asymmetry with the greatest between-individual variation and they were unstable over the age range of 2 years to 18 years. In sample (ii) patients showed higher asymmetries than controls in four ratios (2D:4D, 2D:5D, 3D:5D, 4D:5D) and a sum of asymmetries of the two independent ratios (2D:4D+3D:5D) correlated positively with platelet counts and hospitalization. Conclusion: Means and SDs of digit ratio asymmetry that include the 5th digit are high and age-unstable. Digit ratio asymmetry, particularly 5th digit ratio asymmetry and a composite measure of 2D:4D + 3D:5D asymmetry, may be positively linked to high platelet counts in COVID-19 patients and to an elevated risk of hospitalization. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Kasielska-Trojan, Manning, Jabłkowski, Białkowska-Warzecha, Kwasniewska, Hirschberg and Antoszewski.)
Databáze:	MEDLINE
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