Ceramides and Phosphatidylcholines Associate with Cardiovascular Diseases in the Elderly.

Autor:	Katajamäki TT; Faculty of Medicine, Department of Clinical Medicine, Unit of Clinical Chemistry, Turku University, Turku, Finland.; Department of Clinical Chemistry, Laboratory Division, Turku University Hospital, Hospital District of Southwest Finland, Turku, Finland., Koivula MK; HUS Diagnostic Center, Helsinki University Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.; Clinical Chemistry and Hematology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Hilvo M; Zora Biosciences Oy, Espoo, Finland., Lääperi MTA; Zora Biosciences Oy, Espoo, Finland., Salminen MJ; Faculty of Medicine, Department of Clinical Medicine, Unit of Family Medicine, University of Turku and Turku University Hospital, Turku, Finland.; Welfare Division, Turku City Hospital, Turku, Finland., Viljanen AM; Municipality of Lieto, Health Care Center, Lieto, Finland.; Faculty of Medicine, Department of Geriatrics, Turku City Hospital, University of Turku, Turku, Finland., Heikkilä ETM; Faculty of Medicine, Department of Clinical Medicine, Unit of Clinical Chemistry, Turku University, Turku, Finland.; Department of Clinical Chemistry, Laboratory Division, Turku University Hospital, Hospital District of Southwest Finland, Turku, Finland., Löppönen MK; Social and Health Care for Elderly, Raisio, Finland., Isoaho RE; Faculty of Medicine, Department of Clinical Medicine, Unit of Family Medicine, University of Turku and Turku University Hospital, Turku, Finland.; Social and Health Care, Vaasa, Finland., Kivelä SL; Faculty of Medicine, Department of Clinical Medicine, Unit of Family Medicine, University of Turku and Turku University Hospital, Turku, Finland.; Faculty of Pharmacy, Division of Social Pharmacy, University of Helsinki, Helsinki, Finland., Jylhä A; Zora Biosciences Oy, Espoo, Finland., Viikari L; Faculty of Medicine, Department of Geriatrics, Turku City Hospital, University of Turku, Turku, Finland.; Welfare Division, Turku City Hospital, Turku, Finland., Irjala KM; Faculty of Medicine, Department of Clinical Medicine, Unit of Clinical Chemistry, Turku University, Turku, Finland., Pulkki KJ; HUS Diagnostic Center, Helsinki University Hospital, Hospital District of Helsinki and Uusimaa, Helsinki, Finland.; Clinical Chemistry and Hematology, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Laaksonen RMH; Zora Biosciences Oy, Espoo, Finland.; Finnish Cardiovascular Research Center, University of Tampere, Tampere, Finland.
Jazyk:	angličtina
Zdroj:	Clinical chemistry [Clin Chem] 2022 Dec 06; Vol. 68 (12), pp. 1502-1508.
DOI:	10.1093/clinchem/hvac158
Abstrakt:	Background: The ceramide- and phospholipid-based cardiovascular risk score (CERT2) has been found to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular mortality. In the present study, our aim was to estimate the predictive ability of CERT2 for mortality of CVD, coronary artery disease (CAD), and stroke in the elderly and to compare these results with those of conventional lipids. Methods: We conducted a prospective study with an 18-year follow-up period that included a total of 1260 participants ages ≥64 years. Ceramides and phosphatidylcholines were analyzed using a LC-MS. Total cholesterol and triglycerides were performed by enzymatic methods and HDL cholesterol was determined by a direct enzymatic method. Concentrations of LDL-cholesterol were calculated according to the Friedewald formula. Results: A higher score of CERT2 was significantly associated with higher CVD, CAD, and stroke mortality during the 18-year follow-up both in unadjusted and adjusted Cox regression models. The unadjusted hazard ratios (HRs) of CERT2 (95% CI) per SD for CVD, CAD, and stroke were 1.72 (1.52-1.96), 1.76 (1.52-2.04), and 1.63 (1.27-2.10), respectively, and the corresponding adjusted HRs (95% CI) per SD for CERT2 were 1.48 (1.29-1.69), 1.50 (1.28-1.75), and 1.41 (1.09-1.83). For conventional lipids, HRs per SD were lower than for CERT2. Conclusions: The risk score CERT2 associated strongly with CVD, CAD, and stroke mortality in the elderly, while the association between these events and conventional lipids was weak. (© American Association for Clinical Chemistry 2022. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu