| Autor: |
Gasmi A; Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France., Bjørklund G; Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway., Mujawdiya PK; Birla Institute of Technology and Science -Pilani, Hyderabad, India., Semenova Y; Nazarbayev University School of Medicine, Astana, Kazakhstan., Piscopo S; Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France., Peana M; Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Critical reviews in food science and nutrition [Crit Rev Food Sci Nutr] 2024; Vol. 64 (12), pp. 3907-3919. Date of Electronic Publication: 2022 Oct 27. |
| DOI: |
10.1080/10408398.2022.2137724 |
| Abstrakt: |
Coenzyme Q 10 (CoQ 10 ) is an essential component of the electron transport chain. It also acts as an antioxidant in cellular membranes. It can be endogenously produced in all cells by a specialized mitochondrial pathway. CoQ 10 deficiency, which can result from aging or insufficient enzyme function, has been considered to increase oxidative stress. Some drugs, including statins and bisphosphonates, often used by older individuals, can interfere with enzymes responsible for endogenous CoQ 10 synthesis. Oral supplementation with high doses of CoQ 10 can increase both its circulating and intracellular levels and several clinical trials observed that its administration provided beneficial effects on different disorders such as cardiovascular disease and inflammation which have been associated with low CoQ 10 levels and high oxidative stress. Moreover, CoQ 10 has been suggested as a promising therapeutic agent to prevent and slow the progression of other diseases including metabolic syndrome and type 2 diabetes, neurodegenerative and male infertility. However, there is still a need for further studies and well-designed clinical trials involving a large number of participants undergoing longer treatments to assess the benefits of CoQ 10 for these disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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