Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation.

Autor:	Sindeeva OA; A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia., Abdurashitov AS; A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia., Proshin PI; A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia., Kadrev AV; Ultrasound Diagnostics Department, Medical Research and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia.; Diagnostic Ultrasound Division, Russian Medical Academy of Continuous Professional Education, 1 Barrikadnaya Str., 125445 Moscow, Russia., Kulikov OA; Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia., Shaparov BM; Department of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia., Sorokin NI; Department of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia., Ageev VP; Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia., Pyataev NA; Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia., Kritskiy A; LLC Magnetic Drug Delivery, AMT & C Group, 4 Promyshlennaya Str., Troitsk, 108840 Moscow, Russia., Tishin A; LLC Magnetic Drug Delivery, AMT & C Group, 4 Promyshlennaya Str., Troitsk, 108840 Moscow, Russia., Kamalov AA; Department of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia., Sukhorukov GB; A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia.; Siberian State Medical University, 2 Moskovskiy Trakt, 634050 Tomsk, Russia.; School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
Jazyk:	angličtina
Zdroj:	Pharmaceutics [Pharmaceutics] 2022 Oct 13; Vol. 14 (10). Date of Electronic Publication: 2022 Oct 13.
DOI:	10.3390/pharmaceutics14102186
Abstrakt:	Bladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery. Balloon dilation is a minimally invasive alternative to the surgical dissection of tissues; however, it significantly reduces the patient's quality of life. Additional local anti-inflammatory treatment may reduce the number of procedures requested and increase the attractiveness of this therapeutic strategy. Here, we report about an ultrathin biocompatible coating based on polylactic acid for Foley catheter balloons that can provide localized release of Prednol-L in the range of 56-99 µg in the BNC zone under conventional diagnostic ultrasound exposure. Note that the exposure of a transrectal probe with a conventional gray-scale ultrasound regimen with and without shear wave elastography (SWE) was comparably effective for Prednol-L release from the coating surface of a Foley catheter balloon. This strategy does not require additional manipulations by clinicians. The trigger for the drug release is the ultrasound exposure, which is applied for visualization of the balloon's location during the dilation process. In vivo experiments demonstrated the absence of negative effects of the usage of a coated Foley catheter for balloon dilation of the bladder neck and urethra.
Databáze:	MEDLINE
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