Viral Infection Profile in Children Treated for Acute Lymphoblastic Leukemia-Results of Nationwide Study.

Autor: Zawitkowska J; Department of Pediatric Hematology, Oncology and Transplantation, Medical University, 20-059 Lublin, Poland., Drabko K; Department of Pediatric Hematology, Oncology and Transplantation, Medical University, 20-059 Lublin, Poland., Czyżewski K; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland., Dziedzic M; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland., Jaremek K; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland., Zalas-Więcek P; Department of Microbiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland., Szmydki-Baran A; Department of Hematology and Pediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland., Hutnik Ł; Department of Hematology and Pediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland., Matysiak M; Department of Hematology and Pediatrics, Medical University of Warsaw, 02-091 Warszawa, Poland., Czogała W; Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, 31-008 Krakow, Poland., Balwierz W; Department of Pediatric Oncology and Hematology, Institute of Pediatrics, Jagiellonian University Medical College, 31-008 Krakow, Poland., Żak I; Department of Microbiology, University Children's Hospital, Jagiellonian University Medical College, 31-008 Krakow, Poland., Salamonowicz-Bodzioch M; Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland., Kazanowska B; Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland., Wróbel G; Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland., Kałwak K; Department of Paediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University, 50-367 Wroclaw, Poland., Tomaszewska R; Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, 40-752 Katowice, Poland., Szczepański T; Department of Pediatrics, Hematology and Oncology, Medical University of Silesia, 40-752 Katowice, Poland., Zając-Spychała O; Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland., Wachowiak J; Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland., Płonowski M; Department of Pediatric Oncology, Hematology, Medical University of Bialystok, 15-089 Bialystok, Poland., Krawczuk-Rybak M; Department of Pediatric Oncology, Hematology, Medical University of Bialystok, 15-089 Bialystok, Poland., Królak A; Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland., Ociepa T; Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland., Urasiński T; Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University, 70-204 Szczecin, Poland., Pierlejewski F; Department of Pediatrics, Oncology & Hematology, Medical University of Lodz, 90-647 Lodz, Poland., Młynarski W; Department of Pediatrics, Oncology & Hematology, Medical University of Lodz, 90-647 Lodz, Poland., Urbańska-Rakus J; Unit of Pediatric Hematology and Oncology, City Hospital, 41-500 Chorzow, Poland., Machnik K; Unit of Pediatric Hematology and Oncology, City Hospital, 41-500 Chorzow, Poland., Pająk S; Unit of Pediatric Hematology and Oncology, City Hospital, 41-500 Chorzow, Poland., Badowska W; Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children's Hospital in Olsztyn, 10-561 Olsztyn, Poland., Brzeski T; Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children's Hospital in Olsztyn, 10-561 Olsztyn, Poland., Mycko K; Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children's Hospital in Olsztyn, 10-561 Olsztyn, Poland., Mańko-Glińska H; Clinical Department of Pediatric Oncology and Hematology, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Regional Specialized Children's Hospital in Olsztyn, 10-561 Olsztyn, Poland., Urbanek-Dądela A; Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce, 25-317 Kielce, Poland., Karolczyk G; Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce, 25-317 Kielce, Poland., Mizia-Malarz A; Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children's Care Health, Medical University of Silesia, 40-752 Katowice, Poland., Stolpa W; Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children's Care Health, Medical University of Silesia, 40-752 Katowice, Poland., Skowron-Kandzia K; Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children's Care Health, Medical University of Silesia, 40-752 Katowice, Poland., Musiał J; Clinic of Paediatric Oncology and Haematology, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland., Chaber R; Clinic of Paediatric Oncology and Haematology, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland., Irga-Jaworska N; Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland., Bień E; Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland., Styczyński J; Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
Jazyk: angličtina
Zdroj: Pathogens (Basel, Switzerland) [Pathogens] 2022 Sep 24; Vol. 11 (10). Date of Electronic Publication: 2022 Sep 24.
DOI: 10.3390/pathogens11101091
Abstrakt: Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and the profile of viral infection in children with ALL treated in 17 pediatric oncology centers in Poland in the two-year periods of 2018-2019 and 2020-2021. We also compared the frequency of viral infections in 2018-2019 to that in 2020-2021. In 2020-2021, a total of 192 children with ALL had a viral infection during intensive chemotherapy. A total number of 312 episodes of viral infections were diagnosed. The most common infections detected in the samples were: COVID-19 (23%), rhinovirus (18%), and respiratory syncytial virus (14%). COVID-19 and BK virus infections were the reason for the death 1% of all patients. In 2018-2019, a total of 53 ALL patients who had a viral infection were reported and 72 viral events were observed, mainly adenovirus (48.6%), rotavirus (31.9%), and herpes zoster (8.3%). No deaths were reported during this period. The cumulative incidence of viral infections in 2018-2019 was 10.4%, while for 2020-2021, it was 36.7%. In conclusion, a high incidence of COVID-19 infection was observed among pediatric patients with ALL in Poland. The mortality rate in our material was low. The viral profile in ALL children undergoing chemotherapy can be useful for clinicians to improve prophylactic and therapeutic strategies.
Databáze: MEDLINE