The Impact of Latent Toxoplasma gondii Infection on Spontaneous Abortion History and Pregnancy Outcomes: A Large-Scale Study.

Autor:	Mocanu AG; Department of Obstetrics-Gynecology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Stoian DL; Department of Endocrinology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Craciunescu EL; Department of Prosthesis Technology and Dental Materials, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Ciohat IM; Laboratory of Antenatal Medicine, Timisoara City Emergency Hospital, 300202 Timisoara, Romania., Motofelea AC; Second Department of Internal Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Navolan DB; Department of Obstetrics-Gynecology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Vilibic-Cavlek T; Department of Virology, Croatian Institute of Public Health, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia., Stevanovic V; Virology Laboratory, Department of Microbiology and Infectious Diseases with Clinic, Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia., Nemescu D; Department of Obstetrics-Gynecology, Gr. T. Popa University of Medicine and Pharmacy Iasi, Universitatii Str. nr. 16, 700115 Iasi, Romania., Forga M; Department of Obstetrics-Gynecology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Daniluc R; Department of Obstetrics-Gynecology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Ioana AM; Department of Obstetrics-Gynecology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania., Craina M; Department of Obstetrics-Gynecology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2022 Sep 30; Vol. 10 (10). Date of Electronic Publication: 2022 Sep 30.
DOI:	10.3390/microorganisms10101944
Abstrakt:	Background: Toxoplasma gondii (TG), a zoonotic protozoan parasite, belongs to a group of TORCH infectious agents, which can cause severe damage to the fetus if a primary infection occurs during pregnancy. After primary infection, TG rests lifelong in human organisms causing a latent infection. Most studies have analyzed the consequences of acute, but not latent, TG infection. This study analyzed the impact of latent toxoplasmosis on spontaneous abortion history, pregnancy complication rate and neonatal outcome. Methods: IgG and IgM anti-TG antibodies were tested in 806 pregnant women who were consulted at the Timisoara Clinical Emergency Hospital between 2008 and 2010. Demographic data, obstetrical history, and data about the pregnancy complications, birth and neonate were collected for each woman and comparisons between the groups, with and without latent TG infection, were made. Results: This study did not show differences between groups regarding the history of spontaneous abortion (OR = 1.288, p = 0.333), cesarean section (OR = 1.021, p = 0.884), placental abruption (OR 0.995, p = 0.266), pregnancy-induced hypertension rate (OR 1.083, p = 0.846), secondary sex ratio (1.043, p = 0.776), 1' APGAR score at birth ( p = 0.544), gestational age at birth ( p = 0.491) or birth weight ( p = 0.257). Conclusions: The observed differences between the rate of pregnancy complications in the two groups of pregnant women with and without latent infection with TG, did not reach a statistical significance.
Databáze:	MEDLINE
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