Sarcopenia does not limit overall survival in patients with colorectal liver metastases undergoing interstitial brachytherapy.
| Autor: | Thormann M; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Heitmann F; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Wrobel V; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Barajas Ordonez F; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Pech M; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Surov A; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Damm R; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany., Omari J; University Clinic for Radiology and Nuclear Medicine, University Hospital Magdeburg, Magdeburg, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin [Rofo] 2023 Mar; Vol. 195 (3), pp. 217-223. Date of Electronic Publication: 2022 Oct 25. |
| DOI: | 10.1055/a-1936-2937 |
| Abstrakt: | Purpose: Several studies report an association of sarcopenia with survival in oncologic patients. The aim of this study is to assess the influence of sarcopenia on overall survival (OS) in patients with colorectal liver metastases undergoing interstitial brachytherapy (iBT) METHODS: We identified 144 patients with colorectal liver metastases from our database from 2014-2017. Computed tomography (CT) chest scans at the L3 level were retrospectively analyzed. Psoas muscle area (PMA), psoas muscle index (PMI), and skeletal muscle gauge (SMG) were measured on the CT scan before treatment. Parameters were associated with overall survival. Results: 116 patients were included. Median overall survival was 27 months. Median PMA was 13.79 cm 2 , median PMI 4.51 cm 2 /m 2 . Neither PMA (HR 1.036, 95 % CI 0.996-1.078, p = 0.080), PMI (HR 1.068, 95 % CI 0.922-1.238, p = 0.382), nor SMG (HR 1.00, 95 % CI 0.998-1.003, p = 0.955) were significantly associated with overall survival. Conclusion: Sarcopenic patients undergoing iBT for colorectal liver metastases did not show decreased overall survival. If confirmed by comparative studies, sarcopenia may serve as a biomarker for treatment decision in patients with CRLM. Key Points: Sarcopenia is not a risk factor for survival in patients with CLRM undergoing iBT. Citation Format: · Thormann M, Heitmann F, Wrobel V et al. Sarcopenia does not limit overall survival in patients with colorectal liver metastases undergoing interstitial brachytherapy. Fortschr Röntgenstr 2023; 195: 217 - 223. Competing Interests: The authors declare that they have no conflict of interest. (Thieme. All rights reserved.) |
| Databáze: | MEDLINE |
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