Young-onset colon cancer among people living with HIV in metropolitan Atlanta.

Autor: Mills K; Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA. kmills@msm.edu., Sobukonla T; Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA., Bilal M; Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA., Surapaneni P; Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA., Yan F; Department of Community Health and Preventative Medicine, Morehouse School of Medicine, Atlanta, GA, USA., Bakinde N; Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA., Chan A; Department of Infectious Disease, Morehouse School of Medicine, Atlanta, GA, USA., Jamorabo DS; Department of Gastroenterology, Stony Brook Medicine, Stony Brook, NY, USA., Renelus BD; Department of Gastroenterology, Morehouse School of Medicine, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: International journal of colorectal disease [Int J Colorectal Dis] 2022 Nov; Vol. 37 (11), pp. 2303-2308. Date of Electronic Publication: 2022 Oct 24.
DOI: 10.1007/s00384-022-04273-w
Abstrakt: Purpose: Colon cancer is a leading cause of cancer-related morbidity and mortality in the USA. We sought to better characterize colon cancer among a predominantly Black cohort with and without HIV.
Methods: We retrospectively reviewed all patients (n = 1482) diagnosed with colon cancer between 2015 and 2019 at a large urban tertiary teaching hospital using ICD-9 and ICD-10 codes. In this cohort, 114 (7.7%) of the patients also had HIV. Descriptive summaries were performed for gender, age, race/ethnicity, insurance status, tobacco/alcohol use, and BMI.
Results: Among patients with colon cancer only, 50.51% (n = 691) were men and 49.49% (n = 677) were women. Among patients with both HIV and colon cancer, 78.95% (n = 90) were men and 21.05% (n = 24) were women (p-value < 0.001). The mean age of the colon cancer patient sample was 61.62 years for those without HIV and 51.31 years for those with HIV (p-value < 0.001). Persons with both HIV and colon cancer were more likely to have a lower BMI (p-value < 0.001) and a history of smoking and alcohol use (p-value < 0.001), compared to patients with colon cancer only. When accounting for BMI, tobacco, and alcohol use, those with HIV were 10 years younger than those without HIV, 95% CI, 7.3-13; p < 0.001.
Conclusions: In this study, HIV positive status was a risk factor for developing colon cancer at a younger age. Larger observational studies with multivariable analysis should be done to better describe the risk of colon cancer and HIV.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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