Does Coronavirus Disease 2019 Kill More Elderly Men than Women Due to Different Hormonal Milieu.

Autor: Tandon A; Acharya Shri Chander College of Medical Sciences & Hospital Sidhra Jammu, Sidhra, Jammu and Kashmir, India., Tandon VR; Department of Pharmacology, Government Medical College, Jammu and Kashmir, India., Sharma S; Department of Obstetrics and Gynaecology, Government Medical College, Jammu and Kashmir, India., Mahajan A; Department of Internal Medicine, Government Medical College, Jammu and Kashmir, India.
Jazyk: angličtina
Zdroj: Journal of mid-life health [J Midlife Health] 2022 Apr-Jun; Vol. 13 (2), pp. 96-99. Date of Electronic Publication: 2022 Sep 16.
DOI: 10.4103/jmh.jmh_37_22
Abstrakt: Preliminary data depicts a much greater prevalence and high case-fatality rate in advanced age males as compared to age-matched women with severe acute respiratory syndrome-coronavirus-2 infections with high morbidity, mortality, high referral, and admission to intensive care unit with severe sequelae. However, the literature search revealed both for and against studies in this context. Thus, at present, in light of the mixed studies, it cannot be established whether low testosterone levels in aging hypogonadal males create a permissive environment for severe response to coronavirus disease 2019 (COVID-19) infection and can it increase the morbidity or mortality, or on the contrary if the virus inhibits androgen formation. Hence, it is highly warranted to establish the said hypothesis by conducting large statistically powered clinical studies in future. Further, it is highly indicated that impact of sex hormones and gender on the incidence and case fatality of the disease and hormones as a treatment according to sex and gender for COVID requires further scientific research by the research community before it is actually recommended to mitigate the COVID-19 disease course among elderly men and women at large.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Journal of Mid-life Health.)
Databáze: MEDLINE
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