HYDRHA: Hydrogels of hyaluronic acid. New biomedical approaches in cancer, neurodegenerative diseases, and tissue engineering.

Autor:	Grieco M; National Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, Italy., Ursini O; National Research Council-Nanotechnology Institute (CNR Nanotec), 00185, Rome, Italy., Palamà IE; National Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, Italy., Gigli G; National Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, Italy.; Department of Mathematics and Physics 'Ennio De Giorgi' University of Salento, Via Arnesano, 73100, Lecce, Italy., Moroni L; National Research Council-Nanotechnology Institute (CNR Nanotec), 73100, Lecce, Italy.; Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Universiteitssingel 40, Maastricht, 6229 ER, the Netherlands., Cortese B; National Research Council-Nanotechnology Institute (CNR Nanotec), 00185, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Materials today. Bio [Mater Today Bio] 2022 Oct 08; Vol. 17, pp. 100453. Date of Electronic Publication: 2022 Oct 08 (Print Publication: 2022).
DOI:	10.1016/j.mtbio.2022.100453
Abstrakt:	In the last decade, hyaluronic acid (HA) has attracted an ever-growing interest in the biomedical engineering field as a biocompatible, biodegradable, and chemically versatile molecule. In fact, HA is a major component of the extracellular matrix (ECM) and is essential for the maintenance of cellular homeostasis and crosstalk. Innovative experimental strategies in vitro and in vivo using three-dimensional (3D) HA systems have been increasingly reported in studies of diseases, replacement of tissue and organ damage, repairing wounds, and encapsulating stem cells for tissue regeneration. The present work aims to give an overview and comparison of recent work carried out on HA systems showing advantages, limitations, and their complementarity, for a comprehensive characterization of their use. A special attention is paid to the use of HA in three important areas: cancer, diseases of the central nervous system (CNS), and tissue regeneration, discussing the most innovative experimental strategies. Finally, perspectives within and beyond these research fields are discussed. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Cortese Barbara reports financial support was provided by Airc Italian Foundation for Cancer Research. Gigli Giuseppe reports financial support was provided by Puglia Region. (© 2022 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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