Retrospective detection of monkeypox virus in the testes of nonhuman primate survivors.

Autor: Liu J; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Mucker EM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Chapman JL; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA.; Labcorp Early Development Laboratories Inc., Chantilly, VA, USA., Babka AM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Gordon JM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Bryan AV; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Raymond JLW; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Bell TM; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Facemire PR; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Goff AJ; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Nalca A; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA., Zeng X; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, USA. xiankun.zeng.civ@health.mil.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2022 Dec; Vol. 7 (12), pp. 1980-1986. Date of Electronic Publication: 2022 Oct 17.
DOI: 10.1038/s41564-022-01259-w
Abstrakt: Close contact through sexual activity has been associated with the spread of monkeypox virus (MPXV) in the ongoing, global 2022 epidemic. However, it remains unclear whether MPXV replicates in the testes or is transmitted via semen to produce an active infection. We carried out a retrospective analysis of MPXV-infected crab-eating macaque archival tissue samples from acute and convalescent phases of infection of clade I or clade II MPXV using immunostaining and RNA in situ hybridization. We detected MPXV in interstitial cells and seminiferous tubules of testes as well as epididymal lumina, which are the sites of sperm production and maturation. We also detected inflammation and necrosis during the acute phase of the disease by histological analysis. Finally, we found that MPXV was cleared from most organs during convalescence, including healed skin lesions, but could be detected for up to 37 d post-exposure in the testes of convalescent macaques. Our findings highlight the potential for sexual transmission of MPXV in humans.
(© 2022. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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