Molecular Skin Cancer Diagnosis: Promise and Limitations.
| Autor: | Nataren N; Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia., Yamada M; Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia., Prow T; Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia; Skin Research Centre, York Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom. Electronic address: tarl.prow@hyms.ac.uk. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Journal of molecular diagnostics : JMD [J Mol Diagn] 2023 Jan; Vol. 25 (1), pp. 17-35. Date of Electronic Publication: 2022 Oct 13. |
| DOI: | 10.1016/j.jmoldx.2022.09.008 |
| Abstrakt: | Skin cancer is a significant and increasing global health burden. Although the current diagnostic workflow is robust and able to provide clinically actionable results, it is subject to notable limitations. The training and expertise required for accurate diagnoses using conventional skin cancer diagnostics are significant, and patient access to this workflow can be limited by geographic location or unforeseen events, such as coronavirus disease 2019 (COVID-19). Molecular biomarkers have transformed diagnostics and treatment delivery in oncology. With rapid advancements in molecular biology techniques, understanding of the underlying molecular mechanism of cancer pathologies has deepened, yielding biomarkers that can be used to monitor the course of malignant diseases. Herein, commercially available, clinically validated, and emerging skin cancer molecular biomarkers are reviewed. The qualities of an ideal molecular biomarker are defined. The potential benefits and limitations of applying molecular biomarker testing over the course of skin cancer from susceptibility to treatment are explored, with a view to outlining a future model of molecular biomarker skin cancer diagnostics. (Copyright © 2023 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|