Plant Lectins: A Review on their Biotechnological Potential Toward Human Pathogens.

Autor:	Costa ACM; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Malveira EA; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Mendonça LP; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Maia MES; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Silva RRS; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Roma RR; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Aguiar TKB; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Grangeiro YA; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil., Souza PFN; Department of Biochemistry and Molecular Biology, Federal University of Ceara, Caixa 60430-275 Fortaleza, CE, Brazil.; Drug Research and Development Center, Department of Medicine, Federal University of Ceará, Caixa 60430- 275 Fortaleza, CE, Brazil.
Jazyk:	angličtina
Zdroj:	Current protein & peptide science [Curr Protein Pept Sci] 2022; Vol. 23 (12), pp. 851-861.
DOI:	10.2174/1389203724666221014142740
Abstrakt:	The indiscriminate use of antibiotics is associated with the appearance of bacterial resistance. In light of this, plant-based products treating infections are considered potential alternatives. Lectins are a group of proteins widely distributed in nature, capable of reversibly binding carbohydrates. Lectins can bind to the surface of pathogens and cause damage to their structure, thus preventing host infection. The antimicrobial activity of plant lectins results from their interaction with carbohydrates present in the bacterial cell wall and fungal membrane. The data about lectins as modulating agents of antibiotic activity, potentiates the effect of antibiotics without triggering microbial resistance. In addition, lectins play an essential role in the defense against fungi, reducing their infectivity and pathogenicity. Little is known about the antiviral activity of plant lectins. However, their effectiveness against retroviruses and parainfluenza is reported in the literature. Some authors still consider mannose/ glucose/N-Acetylglucosamine binding lectins as potent antiviral agents against coronavirus, suggesting that these lectins may have inhibitory activity against SARS-CoV-2. Thus, it was found that plant lectins are an alternative for producing new antimicrobial drugs, but further studies still need to decipher some mechanisms of action. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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