Validity of the NIH toolbox cognitive battery in a healthy oldest-old 85+ sample.

Autor:	Nolin SA; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA., Cowart H; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA., Merritt S; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA., McInerney K; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA., Bharadwaj PK; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Franchetti MK; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Raichlen DA; University of Southern California, Los Angeles, CA, USA., Jessup CJ; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Hishaw GA; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Van Etten EJ; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Trouard TP; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Geldmacher DS; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA., Wadley VG; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA., Porges ES; University of Florida, Evelyn F. and William L. McKnight Brain Institute, Gainesville, FL, USA., Woods AJ; University of Florida, Evelyn F. and William L. McKnight Brain Institute, Gainesville, FL, USA., Cohen RA; University of Florida, Evelyn F. and William L. McKnight Brain Institute, Gainesville, FL, USA., Levin BE; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA., Rundek T; University of Miami, Miller School of Medicine, Evelyn F. McKnight Brain Institute, Miami, FL, USA., Alexander GE; University of Arizona, Evelyn F. McKnight Brain Institute, Tucson, AZ, USA., Visscher KM; University of Alabama at Birmingham, Heersink School of Medicine, Evelyn F. McKnight Brain Institute, Birmingham, AL, USA.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2023 Jul; Vol. 29 (6), pp. 605-614. Date of Electronic Publication: 2022 Oct 14.
DOI:	10.1017/S1355617722000443
Abstrakt:	Objective: To evaluate the construct validity of the NIH Toolbox Cognitive Battery (NIH TB-CB) in the healthy oldest-old (85+ years old). Method: Our sample from the McKnight Brain Aging Registry consists of 179 individuals, 85 to 99 years of age, screened for memory, neurological, and psychiatric disorders. Using previous research methods on a sample of 85 + y/o adults, we conducted confirmatory factor analyses on models of NIH TB-CB and same domain standard neuropsychological measures. We hypothesized the five-factor model (Reading, Vocabulary, Memory, Working Memory, and Executive/Speed) would have the best fit, consistent with younger populations. We assessed confirmatory and discriminant validity. We also evaluated demographic and computer use predictors of NIH TB-CB composite scores. Results: Findings suggest the six-factor model (Vocabulary, Reading, Memory, Working Memory, Executive, and Speed) had a better fit than alternative models. NIH TB-CB tests had good convergent and discriminant validity, though tests in the executive functioning domain had high inter-correlations with other cognitive domains. Computer use was strongly associated with higher NIH TB-CB overall and fluid cognition composite scores. Conclusion: The NIH TB-CB is a valid assessment for the oldest-old samples, with relatively weak validity in the domain of executive functioning. Computer use's impact on composite scores could be due to the executive demands of learning to use a tablet. Strong relationships of executive function with other cognitive domains could be due to cognitive dedifferentiation. Overall, the NIH TB-CB could be useful for testing cognition in the oldest-old and the impact of aging on cognition in older populations.
Databáze:	MEDLINE
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