Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: A Prospective Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortium.

Autor:	Hart PA; From the Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH., Papachristou GI; From the Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH., Park WG; Division of Gastroenterology, Stanford University School of Medicine, Palo Alto, CA., Dyer AM; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA., Chinchilli VM; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA., Afghani E; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore., Akshintala VS; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore., Andersen DK; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD., Buxbaum JL; Division of Gastroenterology, University of Southern California, Keck School of Medicine, Los Angeles, CA., Conwell DL; From the Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH., Dungan KM; Division of Endocrinology, Diabetes and Metabolism, The Ohio State University Wexner Medical Center, Columbus, OH., Easler JJ; Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN., Fogel EL; Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN., Greenbaum CJ; Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA., Kalyani RR; Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins Medical Institutions, Baltimore, MD., Korc M; Division of Endocrinology, University of California Irvine, Irvine, CA., Kozarek R, Laughlin MR; Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD., Lee PJ; From the Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH., Maranki JL; Division of Gastroenterology and Hepatology, Department of Medicine, Penn State Milton Hershey Medical Center, Hershey, PA., Pandol SJ; Division of Digestive and Liver Diseases, Cedars-Sinai Medical Center, Los Angeles, CA., Phillips AE; Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA., Serrano J; Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD., Singh VK; Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institutions, Baltimore., Speake C; Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA., Tirkes T; Department of Radiology and Imaging Services, Indiana University, Indianapolis, IN., Toledo FGS; Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA., Trikudanathan G; Division of Gastroenterology, University of Minnesota, Minneapolis, MN., Vege SS; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN., Wang M; Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA., Yazici C; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, IL., Zaheer A; Russell H. Morgan Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD., Forsmark CE; Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL., Bellin MD, Yadav D; Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Jazyk:	angličtina
Zdroj:	Pancreas [Pancreas] 2022 Jul 01; Vol. 51 (6), pp. 568-574.
DOI:	10.1097/MPA.0000000000002079
Abstrakt:	Abstract: Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is increasingly recognized as an important late and chronic complication. There are several challenges that have prevented precisely determining the incidence rate of DM after AP and understanding the underlying mechanisms. The DREAM (Diabetes RElated to Acute Pancreatitis and its Mechanisms) Study is a prospective cohort study designed to address these and other knowledge gaps to provide the evidence needed to screen for, prevent, and treat DM after AP. In the following article, we summarize literature regarding the epidemiology of DM after AP and provide the rationale and an overview of the DREAM study. Competing Interests: E.A. is on the advisory board for Nestle. M.D.B. receives research support from Viacyte and Dexcom and is on advisory board for Insulet. K.M.D. receives research support from Sanofi, Viacyte, Abbott, and Dexcom; has consulting activities with Eli Lilly, Boehringer Ingelheim, Elsevier; and receives honoraria from UptoDate, Elsevier, Medscape, and Academy for Continued Healthcare Learning. C.E.F. receives research support from AbbVie and has consulting activities with Nestle. G.I.P. receives research support from AbbVie and has consulting activities with Nestle. C.S. is on the advisory board for Vertex Pharmaceuticals. F.G.S.T. receives research support from Dompé Pharmaceuticals and has consulting activities with Sanofi, Eli Lilly, and AstraZeneca. The other authors declare no conflict of interest. (Copyright © 2022 Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government.)
Databáze:	MEDLINE
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